سعر سوليو ميدرول 1 جم فيال 2024

Methylprednisolone (as sodium succinate) 1 g powder for injection, single vial, for intravenous or intramuscular use; Pfizer.

• Corticosteroid adverse effects described on the label include HPA axis suppression, Cushingoid state, hyperglycemia, acute myopathy, psychiatric effects and decreased growth velocity in children.International label, same formulation · DailyMed (U.S. NLM)

• Systemic fungal infections; known hypersensitivity to the product or its constituents; intrathecal administration; IM corticosteroid preparations in idiopathic thrombocytopenic purpura; benzyl alcohol-preserved formulations in premature infants.International label, same formulation · DailyMed (U.S. NLM)

• Serious neurologic events, some fatal (spinal cord infarction, paraplegia, quadriplegia, cortical blindness, stroke), have been reported with epidural corticosteroid injection; not approved for epidural use.International label, same formulation · DailyMed (U.S. NLM)
• HPA axis suppression, Cushing syndrome and hyperglycemia may occur; monitor with chronic use and withdraw gradually; increased dosage of rapidly acting corticosteroid may be needed in stress.International label, same formulation · DailyMed (U.S. NLM)
• Live or live attenuated vaccines are contraindicated in patients receiving immunosuppressive doses; response to killed vaccines cannot be predicted.International label, same formulation · DailyMed (U.S. NLM)
• Acute myopathy has been observed with high doses, especially with neuromuscular transmission disorders (e.g., myasthenia gravis) or neuromuscular blockers; psychic derangements (euphoria, insomnia, mood swings, personality changes) may occur.International label, same formulation · DailyMed (U.S. NLM)
• Benzyl alcohol, a preservative in some formulations, has been associated with serious adverse events including gasping syndrome in neonates; check the vial formulation before use in neonates.International label, same formulation · DailyMed (U.S. NLM)

• CYP3A4 inhibitors (e.g., ketoconazole, macrolide antibiotics)CYP3A4 inhibitors may increase corticosteroid plasma concentrations; ketoconazole has been reported to decrease corticosteroid metabolism by up to 60%.DailyMed (U.S. NLM)
• Aspirin and other NSAIDsConcomitant use increases the risk of gastrointestinal side effects; corticosteroids may increase salicylate clearance.DailyMed (U.S. NLM)
• Live vaccinesLive or live attenuated vaccines are contraindicated with immunosuppressive corticosteroid doses.DailyMed (U.S. NLM)

• Corticosteroids are teratogenic in many animal species (cleft palate); no adequate studies in pregnant women; use only if the potential benefit justifies the potential fetal risk; observe infants of treated mothers for hypoadrenalism.International label, same formulation · DailyMed (U.S. NLM)
• Systemic corticosteroids appear in human milk and could suppress growth or endogenous corticosteroid production; decide whether to continue nursing or the drug.International label, same formulation · DailyMed (U.S. NLM)

• During prolonged therapy: periodic urinalysis, two-hour postprandial blood glucose, blood pressure, body weight and chest X-ray; upper GI X-ray in patients with ulcer history or significant dyspepsia; monitor growth in children.International label, same formulation · DailyMed (U.S. NLM)

• Methylprednisolone sodium succinate: Synthetic glucocorticoid with anti-inflammatory and immunosuppressive effects mediated through glucocorticoid receptors.