سعر سوتالوك 160مجم أقراص 2022

Sotalol 160 mg oral tablets (Alfacure Pharmaceuticals, Egypt); class III antiarrhythmic with non-selective beta-blocking activity.

• Treatment of documented life-threatening ventricular arrhythmias such as sustained ventricular tachycardia.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Maintenance of normal sinus rhythm (delay in recurrence) in patients with highly symptomatic atrial fibrillation/atrial flutter currently in sinus rhythm.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=2%): fatigue, bradycardia, dyspnoea, proarrhythmia, asthenia and dizziness.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sinus bradycardia, sick sinus syndrome, second- or third-degree AV block (unless a functioning pacemaker is present); congenital or acquired long QT syndrome; cardiogenic shock or decompensated heart failure; serum potassium <4 mEq/L; bronchial asthma or related bronchospastic conditions; hypersensitivity to sotalol. For AF/AFL also baseline QT >450 msec.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: can cause life-threatening ventricular tachycardia with QT prolongation (torsade de pointes); if QT reaches 500 msec or more reduce the dose, lengthen the interval or stop.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• May cause bradycardia, AV block, hypotension and new or worsening heart failure; correct hypokalaemia/hypomagnesaemia; do not stop abruptly (risk of exacerbating coronary artery disease); may mask hypoglycaemia in diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Class I or III antiarrhythmics and other QT-prolonging drugsAvoid concomitant use (additive QT prolongation).DailyMed (U.S. National Library of Medicine)
• Digoxin; calcium channel blockersIncreased risk of bradycardia, hypotension and heart failure.DailyMed (U.S. National Library of Medicine)
• ClonidineIncreased risk of bradycardia and AV block; withdraw sotalol several days before gradual clonidine withdrawal.DailyMed (U.S. National Library of Medicine)

• Sotalol crosses the placenta; observational data suggest possible fetal growth restriction, transient fetal bradycardia, hyperbilirubinaemia, hypoglycaemia and possible intrauterine death; untreated arrhythmia in pregnancy also carries risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Sotalol is present in human milk at high levels; the US label advises not to breastfeed during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sotalol: Vaughan Williams class II (beta-blockade) and class III (action-potential prolongation) effects; prolongs the QT interval and slows heart rate.