سعر شوجارلو بلس 5/500مجم 30 قرص 50 مجم/500 مجم 2024

Sugarlo Plus vildagliptin 50 mg / metformin HCl 500 mg film-coated tablets, pack of 30 (Al Esraa Pharmaceutical Optima, Egypt).

• Adjunct to diet and exercise in adults with type 2 diabetes inadequately controlled on metformin alone, already on both components, or in combination with other antidiabetic medicines including insulinPopulation: AdultsEuropean Medicines Agency

• Hypersensitivity to the active substances or excipients.International label, equivalent formulation · European Medicines Agency
• Any acute metabolic acidosis (lactic acidosis, diabetic ketoacidosis) or diabetic pre-coma.International label, equivalent formulation · European Medicines Agency
• Severe renal failure (GFR <30 mL/min) and acute conditions that may alter renal function (dehydration, severe infection, shock, intravascular iodinated contrast).International label, equivalent formulation · European Medicines Agency

• Lactic acidosis risk from metformin accumulation; temporarily stop in dehydration and around iodinated contrast (restart no earlier than 48 h after, once renal function is stable).International label, equivalent formulation · European Medicines Agency
• Liver function tests before initiation and at three-month intervals in the first year, then periodically; withdraw if AST/ALT >=3x ULN persists or jaundice occurs, and do not reinitiate.International label, equivalent formulation · European Medicines Agency
• Acute pancreatitis risk: discontinue if suspected and do not restart if confirmed.International label, equivalent formulation · European Medicines Agency

• ACE inhibitorsPossible increased risk of angioedema with concomitant use.European Medicines Agency
• Thiazides, corticosteroids, thyroid products, sympathomimeticsMay reduce the hypoglycaemic effect of vildagliptin.European Medicines Agency

• No adequate data in pregnant women; vildagliptin showed reproductive toxicity at high doses in animals; potential human risk unknown; should not be used during pregnancy.International label, equivalent formulation · European Medicines Agency