سعر سوابيفنت محلول استنشاق 20 امبولة 2024

Pre-measured unit-dose nebuliser solution combining ipratropium bromide 500 micrograms and salbutamol 2.5 mg (as 3 mg sulfate) per 2.5 ml, made by Uniswab, Egypt; 20 unit doses per pack.

• Management of bronchospasm in COPD patients who require regular treatment with both ipratropium and salbutamolPopulation: Adults and children over 12 yearselectronic medicines compendium (eMC), UK
• Treatment of bronchospasm associated with COPD in patients requiring more than one bronchodilatorPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent: headache, throat irritation, cough, dry mouth, GI motility disorders, nausea, dizziness. Uncommon: nervousness, tremor, palpitations, tachycardia, dysphonia, increased systolic BP. Rare: hypersensitivity/anaphylaxis, hypokalaemia, arrhythmia/atrial fibrillation, myocardial ischaemia, ocular effects, urinary retention, paradoxical bronchospasm.International label, same formulation · electronic medicines compendium (eMC), UK

• Contraindicated in hypertrophic obstructive cardiomyopathy or tachyarrhythmia, and in hypersensitivity to ipratropium bromide, salbutamol sulfate, atropine or its derivatives.International label, same formulation · electronic medicines compendium (eMC), UK

• Paradoxical bronchospasm may occur; stop immediately and use alternative therapy.International label, same formulation · electronic medicines compendium (eMC), UK
• Prevent mist entering the eyes: risk of mydriasis, blurred vision, eye pain and acute narrow-angle glaucoma, particularly in predisposed patients.International label, same formulation · electronic medicines compendium (eMC), UK
• Use only after careful risk/benefit assessment in poorly controlled diabetes, recent MI or severe heart/vascular disease, hyperthyroidism, phaeochromocytoma, prostatic hypertrophy or bladder-neck obstruction.International label, same formulation · electronic medicines compendium (eMC), UK

• Beta-blockersPotentially serious reduction in effect.electronic medicines compendium (eMC), UK
• Other anticholinergic drugsChronic co-administration not studied and not recommended.electronic medicines compendium (eMC), UK
• MAO inhibitors, tricyclic antidepressantsAction of beta-2 agonists may be enhanced; use with caution.electronic medicines compendium (eMC), UK

• No definite evidence of harm in pregnancy for ipratropium; salbutamol widely used, with harmful foetal effects only at very high doses in animals; avoid in pregnancy, especially the first trimester, unless benefit outweighs risk.International label, same formulation · electronic medicines compendium (eMC), UK
• Should not be given to breast-feeding mothers unless expected benefit outweighs possible risk to the neonate.International label, same formulation · electronic medicines compendium (eMC), UK
• US label: unknown whether excreted in milk; ipratropium unlikely to reach the infant in important amounts when nebulised; decide whether to discontinue nursing or the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Ipratropium bromide: Blocks muscarinic receptors in bronchial smooth muscle, reducing vagally mediated bronchoconstriction; minimal systemic absorption when inhaled.
• Salbutamol (as sulfate): Stimulates beta-2 adrenergic receptors in airway smooth muscle, increasing cyclic AMP and causing bronchodilation.