سعر تاجريسو 40مجم 30 قرص 2025

Osimertinib 40 mg film-coated tablets, pack of 30 (3 strips) (AstraZeneca).

• Adjuvant therapy after tumour resection in NSCLC with EGFR exon 19 deletions or exon 21 L858R mutationsPopulation: AdultsDailyMed (NLM)
• Locally advanced unresectable (stage III) EGFR-mutated NSCLC not progressed after platinum-based chemoradiationPopulation: AdultsDailyMed (NLM)
• First-line metastatic NSCLC with EGFR exon 19 deletions or exon 21 L858R mutations (monotherapy or with pemetrexed and platinum chemotherapy)Population: AdultsDailyMed (NLM)

• Most common (>=20%) with monotherapy: leukopenia, lymphopenia, thrombocytopenia, anaemia, diarrhoea, rash, musculoskeletal pain, neutropenia, nail toxicity, dry skin, stomatitis, fatigue.International label, same formulation · DailyMed (NLM)

• None listed in the US label.International label, same formulation · DailyMed (NLM)

• Interstitial lung disease/pneumonitis: monitor; permanently discontinue if diagnosed (rules differ after recent chemoradiation).International label, same formulation · DailyMed (NLM)
• QTc prolongation: monitor ECG and electrolytes in at-risk patients; withhold, reduce or discontinue by severity.International label, same formulation · DailyMed (NLM)
• Cardiomyopathy (3.8%): assess LVEF in patients with cardiac risk factors.International label, same formulation · DailyMed (NLM)

• Strong CYP3A inducersAvoid; if unavoidable increase osimertinib to 160 mg daily.DailyMed (NLM)
• BCRP or P-gp substratesOsimertinib increases their exposure; monitor for substrate toxicity.DailyMed (NLM)

• Can cause fetal harm based on animal data and mechanism; embryolethality and reduced fetal growth in rats at about 1.5 times clinical exposure.International label, same formulation · DailyMed (NLM)
• Advise women not to breastfeed during treatment and for 2 weeks after the last dose.International label, same formulation · DailyMed (NLM)

• Osimertinib: Binds irreversibly to mutant EGFR (T790M, L858R, exon 19 deletions) at about 9-fold lower concentrations than wild-type (US TAGRISSO label).