سعر اتاكاند بلس 12.5/16مجم 14 قرص 2023

Candesartan cilexetil 16 mg + hydrochlorothiazide 12.5 mg tablets, 14 tablets (1 strip); fixed-dose ARB/thiazide combination for hypertension (AstraZeneca).

• Hypertension, to lower blood pressure (not indicated for initial therapy).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Controlled trials (>2% and more than placebo): upper respiratory tract infection, back pain, influenza-like symptoms, dizziness.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Candesartan post-marketing (very rare): hepatitis/abnormal liver function, neutropenia, leukopenia, agranulocytosis, angioedema, hyperkalaemia, hyponatraemia, cough, pruritus, rash, urticaria. Hydrochlorothiazide: pancreatitis, cholestatic jaundice, blood dyscrasias, photosensitivity, anaphylaxis, Stevens-Johnson syndrome/toxic epidermal necrolysis, blurred vision, impotence, non-melanoma skin cancer.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to candesartan, hydrochlorothiazide or other sulfonamide-derived drugs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Co-administration with aliskiren in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anuria.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity: discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension in volume- or salt-depleted patients (correct before starting); in heart failure start under close supervision.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Impaired renal function, including acute renal failure; monitor renal function periodically.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• NSAIDs including selective COX-2 inhibitorsMay worsen renal function (possible acute renal failure) in elderly, volume-depleted or renally impaired patients and attenuate the antihypertensive effect; monitor renal function.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium and toxicity with angiotensin II antagonists or hydrochlorothiazide; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• ACE inhibitors, angiotensin receptor blockers or aliskiren (dual RAS blockade)Increased hypotension, hyperkalaemia and renal function changes; do not use aliskiren in diabetes and avoid in GFR <60 mL/min.DailyMed (U.S. National Library of Medicine)

• Boxed warning: fetal toxicity. Drugs acting on the renin-angiotensin system during the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Thiazides appear in human milk and candesartan is present in rat milk; decide whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Candesartan cilexetil: Prodrug hydrolysed to candesartan during absorption; candesartan selectively blocks the binding of angiotensin II to the AT1 receptor, inhibiting its vasoconstrictor and aldosterone-secreting effects.
• Hydrochlorothiazide: Thiazide diuretic that affects renal tubular electrolyte reabsorption, increasing excretion of sodium and chloride.