سعر اتاكاند 8 مجم 28 قرص 2024

Candesartan cilexetil 8 mg tablets, 28 tablets (2 strips); angiotensin II receptor blocker for hypertension and heart failure (AstraZeneca).

• Hypertension, to lower blood pressure.Population: Adults and children 1 to <17 yearsDailyMed (U.S. National Library of Medicine)
• Heart failure (NYHA class II-IV) with left ventricular ejection fraction ≤40%, to reduce cardiovascular death and heart-failure hospitalisation.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Hypertension trials (≥1% and more than placebo): back pain, dizziness, upper respiratory tract infection, pharyngitis, rhinitis. Heart failure: hypotension, abnormal renal function and hyperkalaemia were leading causes of discontinuation.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Very rare post-marketing reports: abnormal hepatic function/hepatitis, neutropenia, leukopenia, agranulocytosis, angioedema, hyperkalaemia, hyponatraemia, cough, pruritus, rash, urticaria; rare rhabdomyolysis with angiotensin II receptor blockers.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to candesartan.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Co-administration with aliskiren in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity: discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Children under 1 year must not receive candesartan for hypertension (effects on developing kidneys).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension, especially in volume- or salt-depleted patients (correct before starting); hypotension may also occur during major surgery and anaesthesia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potassium-sparing diuretics, potassium supplements, potassium-containing salt substitutes and other drugs raising potassiumMay cause hyperkalaemia; monitor serum potassium.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium concentrations and toxicity; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• NSAIDs including selective COX-2 inhibitorsIn elderly, volume-depleted or renally impaired patients may worsen renal function (possible acute renal failure) and may attenuate the antihypertensive effect; monitor renal function.DailyMed (U.S. National Library of Medicine)

• Boxed warning: fetal toxicity. Drugs acting on the renin-angiotensin system during the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not known whether candesartan is excreted in human milk (present in rat milk); breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Candesartan cilexetil: Prodrug hydrolysed to candesartan during absorption; candesartan selectively blocks the binding of angiotensin II to the AT1 receptor, inhibiting its vasoconstrictor and aldosterone-secreting effects.