سعر تيبوليان Tibolian‏ 2.5مجم 28 قرص 2026

Tibolone 2.5 mg tablets (CID, Egypt), tissue-selective hormone replacement therapy.

• Common (1-10%): lower abdominal pain, abnormal hair growth, vaginal discharge, endometrial wall thickening, postmenopausal haemorrhage, breast tenderness, genital pruritus, vaginal candidiasis/haemorrhage, pelvic pain, cervical dysplasia, vulvovaginitis, weight increase, abnormal cervical smear.International label, same formulation · electronic medicines compendium (emc), UK

• Pregnancy and lactation; known, past or suspected breast cancer; oestrogen-dependent malignant tumours; undiagnosed genital bleeding; untreated endometrial hyperplasia; previous or current venous thromboembolism; known thrombophilic disorders; any history of arterial thromboembolic disease (angina, MI, stroke, TIA); acute or past liver disease with abnormal liver tests; porphyria; hypersensitivity.International label, same formulation · electronic medicines compendium (emc), UK

• Initiate only for symptoms that adversely affect quality of life and reassess benefits and risks at least annually, considering the risks of stroke, breast cancer and (with an intact uterus) endometrial cancer.International label, same formulation · electronic medicines compendium (emc), UK
• Stroke risk: a 2.9-year study estimated a 2.2-fold increase in stroke risk with tibolone 1.25 mg versus placebo in older women; baseline risk is strongly age-dependent.International label, same formulation · electronic medicines compendium (emc), UK

• Anticoagulants (e.g. warfarin)Tibolone may increase fibrinolytic activity and enhance anticoagulant effect; use caution and adjust warfarin dose if necessary.electronic medicines compendium (emc), UK
• CYP3A4 inducers (barbiturates, carbamazepine, hydantoins, rifampicin, St John's wort)May enhance tibolone metabolism and reduce its therapeutic effect.electronic medicines compendium (emc), UK

• Contraindicated in pregnancy; withdraw immediately if pregnancy occurs. No clinical data on exposed pregnancies; animal studies showed reproductive toxicity.International label, same formulation · electronic medicines compendium (emc), UK
• Contraindicated during breastfeeding.International label, same formulation · electronic medicines compendium (emc), UK

• Tibolone: Rapidly metabolised to 3alpha-OH- and 3beta-OH-tibolone (oestrogenic-like) and the delta4-isomer (progestogenic and androgenic-like); substitutes for lost oestrogen production after menopause.