سعر تراندوجيد Trandoged‏ 1مجم 10 اقراص 2026

Trandoged (trandolapril) 1 mg film-coated tablets, pack of 10 (Jedco International, Egypt).

• Common: headache, dizziness, hypotension, cough; uncommon: somnolence, palpitations, vertigo, hot flushes.International label, equivalent formulation · electronic medicines compendium (emc)

• Hypersensitivity to trandolapril, other ACE inhibitors or excipients; history of ACE-inhibitor angioedema; hereditary or idiopathic angioedema.International label, equivalent formulation · electronic medicines compendium (emc)
• Second and third trimester of pregnancy.International label, equivalent formulation · electronic medicines compendium (emc)
• With aliskiren in diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m2).International label, equivalent formulation · electronic medicines compendium (emc)

• Fetal toxicity (US boxed warning): drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as pregnancy is detected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia may occur, particularly with potassium-sparing diuretics, potassium supplements, salt substitutes or trimethoprim; monitor serum potassium.International label, equivalent formulation · electronic medicines compendium (emc)
• Symptomatic hypotension may follow the first dose, especially in patients on diuretics; stop the diuretic 2-3 days before starting if possible, or start at 0.5 mg under supervision.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Sacubitril/valsartan, racecadotril, mTOR inhibitors, vildagliptinIncreased risk of angioedema; sacubitril/valsartan is contraindicated (36-hour gap).electronic medicines compendium (emc)
• Potassium-sparing diuretics, potassium supplements, trimethoprimRisk of significant increase in serum potassium; combination not recommended or use with frequent potassium monitoring.electronic medicines compendium (emc)

• ACE inhibitors are not recommended in the first trimester and are contraindicated in the second and third trimesters (foetotoxicity: decreased renal function, oligohydramnios, skull ossification retardation; neonatal renal failure, hypotension, hyperkalaemia). Stop immediately when pregnancy is diagnosed.International label, equivalent formulation · electronic medicines compendium (emc)
• No information on use during breast-feeding; not recommended, alternatives preferred especially for newborn or preterm infants.International label, equivalent formulation · electronic medicines compendium (emc)

• Trandolapril: Ethyl ester prodrug hydrolysed to trandolaprilat, which inhibits angiotensin-converting enzyme.