سعر بيجاستوس 1.25 مجم 7 أقراص 2022

Ramipril 1.25 mg tablets (ACE inhibitor) manufactured by Sabaa for hypertension and related labelled uses.

• Treatment of hypertension; cardiovascular prevention in high-risk patients; treatment of certain renal diseases (diabetic/non-diabetic nephropathy as defined in SmPC); symptomatic heart failure; secondary prevention after AMI with heart failure signs.UK eMC / MHRA

• Common: headache, dizziness, non-productive cough, hypotension, gastrointestinal discomfort, fatigue, rash, myalgia.General active-ingredient information · UK eMC / MHRA

• Hypersensitivity to ramipril/excipients/other ACE inhibitors; history of angioedema; concomitant sacubitril/valsartan; extracorporeal treatments with negatively charged membranes; significant bilateral renal-artery stenosis; 2nd/3rd trimester pregnancy; aliskiren in diabetes or GFR <60; hypotensive/haemodynamically unstable states.General active-ingredient information · UK eMC / MHRA

• Risk of hypotension, hyperkalaemia, renal impairment, angioedema, cough; do not initiate in pregnancy; monitor electrolytes/renal function; dual RAAS blockade not recommended.General active-ingredient information · UK eMC / MHRA

• Potassium-sparing diuretics / potassium supplements / aliskiren / ARBsMajorIncreased hyperkalaemia and renal risk; aliskiren contraindicated in diabetes or GFR <60; dual blockade generally avoid.UK eMC / MHRA
• Sacubitril/valsartanMajorContraindicated combination due to angioedema risk; observe washout intervals in SmPC.UK eMC / MHRA

• Not recommended in first trimester; contraindicated in second and third trimesters (fetotoxicity: renal dysfunction, oligohydramnios, skull ossification delay; neonatal toxicity).General active-ingredient information · UK eMC / MHRA
• Insufficient information; not recommended during breastfeeding — prefer alternatives with better-established lactation safety.General active-ingredient information · UK eMC / MHRA

• Ramipril: Prodrug hydrolysed to ramiprilat, which inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion.