سعر ترايسيكونس نوفو Trisequens‏ 28 ق 2026

Trisequens (estradiol / norethisterone acetate) sequential HRT tablets, 28-tablet pack, Novo Nordisk (Egypt listing).

• Most frequently reported in clinical trials: vaginal bleeding and breast pain/tenderness (about 10-20% of patients).International label, same product · electronic medicines compendium (emc)

• Known, past or suspected breast cancer; known or suspected oestrogen-dependent malignant tumours (e.g. endometrial cancer); undiagnosed genital bleeding; untreated endometrial hyperplasia.International label, same product · electronic medicines compendium (emc)
• Previous or current venous thromboembolism; known thrombophilic disorders; active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction).International label, same product · electronic medicines compendium (emc)
• Acute liver disease or history of liver disease while liver function tests remain abnormal; porphyria; hypersensitivity to the active substances or excipients.International label, same product · electronic medicines compendium (emc)

• HRT is associated with increased risks of breast cancer, endometrial cancer (with unopposed oestrogen), ovarian cancer, venous thromboembolism, ischaemic stroke and coronary artery disease; benefits and risks should be reassessed at least annually.International label, same product · electronic medicines compendium (emc)
• Therapy should be discontinued in case of jaundice or deterioration in liver function, significant increase in blood pressure, new onset of migraine-type headache, or pregnancy.International label, same product · electronic medicines compendium (emc)
• HRT does not improve cognitive function; increased risk of probable dementia in women starting continuous combined or oestrogen-only HRT after 65 years.International label, same product · electronic medicines compendium (emc)

• Enzyme inducers (e.g. phenobarbital, phenytoin, carbamazepine, rifampicin, rifabutin, nevirapine, efavirenz) and St John's WortMay increase metabolism of oestrogens and progestagens, decreasing effect and changing the uterine bleeding profile.electronic medicines compendium (emc)
• LamotrigineSeizure control may be affected (oestrogens may lower lamotrigine levels).electronic medicines compendium (emc)
• Ketoconazole and other CYP3A4 inhibitorsMay increase exposure to estradiol.electronic medicines compendium (emc)

• Not indicated during pregnancy; if pregnancy occurs, treatment should be withdrawn immediately.International label, same product · electronic medicines compendium (emc)
• Not indicated during lactation.International label, same product · electronic medicines compendium (emc)

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