سعر فيكسيدوجريل Vexidogrel‏ 75مجم 30 قرص 2026

Clopidogrel 75 mg film-coated tablets, a P2Y12 ADP-receptor antiplatelet agent, marketed in Egypt by European Egyptian Pharm. Ind.

• Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Active pathological bleeding (e.g. peptic ulcer, intracranial haemorrhage); hypersensitivity to clopidogrel or any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: diminished effect in CYP2C19 poor metabolizers. Avoid omeprazole/esomeprazole; increased bleeding risk; premature discontinuation raises cardiovascular risk (stop 5 days before elective surgery with major bleeding risk); TTP has been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Omeprazole / esomeprazole (CYP2C19 inhibitors)Reduce active metabolite levels and antiplatelet effect; avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• NSAIDs, warfarin, SSRIs/SNRIs, other antiplateletsIncrease bleeding risk.DailyMed (U.S. National Library of Medicine)
• OpioidsDecreased clopidogrel exposure; consider a parenteral antiplatelet agent in ACS.DailyMed (U.S. National Library of Medicine)

• Published cases and postmarketing data have not identified a drug-associated risk of major birth defects or miscarriage; MI and stroke themselves carry maternal and fetal risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Clopidogrel: Prodrug converted (mainly via CYP2C19) to an active metabolite that irreversibly blocks the platelet P2Y12 ADP receptor for the platelet lifespan.