سعر امريزول 1جرام 5 اقماع لبوس شرجي 2023

Metronidazole 1 g rectal suppositories (Amrizole, Amriya, Egypt), a nitroimidazole antibacterial/antiprotozoal; 5 suppositories per pack.

• Prevention and treatment of infections due to anaerobic bacteria (particularly Bacteroides species, anaerobic streptococci, Fusobacteria and Clostridia).Population: Adults and childrenHealth Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC

• Gastrointestinal effects (epigastric pain, nausea, vomiting, diarrhoea, taste disorders, dry mouth, anorexia), hypersensitivity reactions (rash, pruritus, urticaria, rarely anaphylaxis), peripheral sensory neuropathy, headache, dizziness, convulsions, rare encephalopathy and cerebellar syndrome, psychotic disorders, transient visual disorders, very rare blood dyscrasias and cholestatic hepatitis.International label, same formulation · Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC

• Known hypersensitivity to metronidazole.International label, same formulation · Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC
• Caution (listed under contraindications in the Irish SmPC) in active or chronic severe peripheral or central nervous system disease, because of the risk of neurological aggravation.International label, same formulation · Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC

• Prolonged therapy: consider peripheral neuropathy or leucopenia (usually reversible); high doses have been associated with transient epileptiform seizures. Intensive or prolonged therapy only under close surveillance and specialist direction.International label, same formulation · Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC
• Avoid alcohol during treatment and for at least 48 hours afterwards (disulfiram-like reaction). Urine may darken.International label, same formulation · Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC
• May cause confusion, dizziness, hallucinations, convulsions or transient visual disorders; do not drive or operate machinery if these occur.International label, same formulation · Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC

• Coumarin anticoagulants (e.g. warfarin)Potentiation of anticoagulant effect; monitor anticoagulant activity.Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC
• AlcoholDisulfiram-like reaction (flushing, vomiting, tachycardia); avoid during and for 48 hours after therapy.Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC
• DisulfiramPsychotic reactions reported with concurrent use.Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC

• Use in pregnancy only after careful evaluation and if considered essential; avoid high-dose regimens. Metronidazole crosses the placenta.International label, same formulation · Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC
• Excreted in breast milk at concentrations equal to serum; use only if essential and avoid unnecessary exposure.International label, same formulation · Health Products Regulatory Authority (Ireland) - Irish Medicines Board SmPC

• Metronidazole: After passive diffusion into susceptible anaerobes it is reduced intracellularly (via electron-transport proteins such as ferredoxin) to a short-lived nitroso free radical; the reduced drug and free radicals can interact with DNA, inhibiting DNA synthesis and causing DNA degradation and bacterial death; the precise mechanism is unclear (US label).