سعر رانديل 10مجم 30 قرص 2024

Nicorandil 10 mg tablets, box of 30 (3 strips) (Adwia, Egypt); potassium-channel-opening antianginal vasodilator.

• Symptomatic treatment in adults of stable angina pectoris inadequately controlled by, or with contraindication or intolerance to, first-line antianginal therapies (such as beta-blockers and/or calcium antagonists).Population: Adultselectronic medicines compendium (emc)

• Very common: headache (more than 30% in trials, mainly in the first days; titration may reduce it). Common: dizziness, heart rate increased, cutaneous vasodilation with flushing, nausea, vomiting, feeling of weakness.International label, same formulation · electronic medicines compendium (emc)
• Uncommon to not known: gastrointestinal ulcerations and haemorrhage, diverticulitis, GI perforation, fistulae, abscesses, skin and mucosal ulcerations, corneal/conjunctival ulcers, decreased blood pressure, rash, pruritus, myalgia, angioedema, liver disorders, hyperkalaemia, diplopia.International label, same formulation · electronic medicines compendium (emc)

• Hypersensitivity to nicorandil or excipients.International label, same formulation · electronic medicines compendium (emc)
• Shock (including cardiogenic shock), severe hypotension, or left ventricular dysfunction with low filling pressure or cardiac decompensation; hypovolaemia; acute pulmonary oedema.International label, same formulation · electronic medicines compendium (emc)
• Use of phosphodiesterase-5 inhibitors or soluble guanylate cyclase stimulators (e.g. riociguat), because of serious fall in blood pressure.International label, same formulation · electronic medicines compendium (emc)

• Gastrointestinal, skin, mucosal and eye (corneal/conjunctival) ulcerations have been reported; they are refractory and usually respond only to withdrawal of nicorandil, which should be stopped if ulceration develops. Ulcers may progress to perforation, fistula, abscess or haemorrhage; patients with diverticular disease may be at particular risk.International label, same formulation · electronic medicines compendium (emc)
• Caution with acetylsalicylic acid/NSAIDs (risk of GI haemorrhage) and corticosteroids (GI perforation reported).International label, same formulation · electronic medicines compendium (emc)
• Caution with other blood-pressure-lowering medicines, in NYHA class III-IV heart failure, with medicines that raise potassium (severe hyperkalaemia reported very rarely), and in G6PD deficiency (methaemoglobinaemia risk).International label, same formulation · electronic medicines compendium (emc)

• PDE-5 inhibitors (sildenafil, tadalafil, vardenafil)Serious drop in blood pressure; contraindicated.electronic medicines compendium (emc)
• Riociguat (soluble guanylate cyclase stimulators)Serious drop in blood pressure; contraindicated.electronic medicines compendium (emc)
• Antihypertensives, vasodilators, tricyclic antidepressants, alcoholBlood-pressure-lowering effect may be increased.electronic medicines compendium (emc)

• No or limited human data; animal studies do not indicate reproductive toxicity. As a precaution, avoid use during pregnancy.International label, same formulation · electronic medicines compendium (emc)
• Excreted in small amounts in animal milk; human excretion unknown; not recommended during breast-feeding.International label, same formulation · electronic medicines compendium (emc)

• Nicorandil: Dual action: opens potassium channels (arterial dilation, afterload reduction) and, through its nitrate moiety, increases intracellular cGMP (venous relaxation, preload reduction); also dilates normal and stenotic coronary segments (UK SmPC).