سعر انجي بروتيكت 20 مجم 20 قرص 2022

Nicorandil 20 mg tablets (potassium-channel opener antianginal), pack of 20 tablets (2 strips), produced in Egypt by Future Pharmaceutical Industries (FPI).

• Symptomatic treatment of stable angina pectoris in adults inadequately controlled by, or with a contraindication or intolerance to, first-line antianginal therapies (such as beta-blockers and/or calcium antagonists)Population: Adultselectronic medicines compendium (emc), UK

• Headache in more than 30% of patients, particularly in the first days of treatment (progressive titration may reduce it); dizziness common.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to nicorandil or excipients.International label, same formulation · electronic medicines compendium (emc), UK
• Shock (including cardiogenic), severe hypotension, left ventricular dysfunction with low filling pressure or cardiac decompensation.International label, same formulation · electronic medicines compendium (emc), UK
• Concomitant PDE5 inhibitors or soluble guanylate cyclase stimulators (riociguat); hypovolaemia; acute pulmonary oedema.International label, same formulation · electronic medicines compendium (emc), UK

• Gastrointestinal, skin, mucosal and eye ulcerations (including perforation, fistula, abscess) may occur; discontinue nicorandil if ulceration develops.International label, same formulation · electronic medicines compendium (emc), UK
• Hyperkalaemia, particularly with renal impairment or potassium-raising drugs; caution in G6PD deficiency and in NYHA III/IV heart failure.International label, same formulation · electronic medicines compendium (emc), UK

• PDE5 inhibitors (sildenafil, tadalafil, vardenafil), riociguatContraindicated: serious drop in blood pressure.electronic medicines compendium (emc), UK
• Aspirin/NSAIDs, corticosteroidsIncreased risk of severe GI ulceration, perforation and haemorrhage.electronic medicines compendium (emc), UK
• Antihypertensives, vasodilators, tricyclic antidepressants, alcohol; dapoxetineIncreased blood-pressure lowering; reduced orthostatic tolerance with dapoxetine.electronic medicines compendium (emc), UK

• Avoid use during pregnancy as a precautionary measure.International label, same formulation · electronic medicines compendium (emc), UK
• Breast-feeding is not recommended during treatment.International label, same formulation · electronic medicines compendium (emc), UK

• Nicorandil: Dual action: opens ATP-sensitive potassium channels (arterial vasodilation, reduced afterload) and, through its nitrate moiety, increases cyclic GMP (venous relaxation, reduced preload); also dilates coronary arteries.