سعر ديليكورل 20 مجم 10 أقراص 2022

Dilikorell 20 mg tablets (nicorandil) by Hikma Pharma; pack of 10.

• Symptomatic treatment of stable angina pectoris in adults inadequately controlled on, or intolerant/contraindicated to, first-line antianginal therapies (beta-blockers and/or calcium antagonists).Population: AdultsMHRA / emc

• Very common: headache (>30%, especially early). Common: dizziness, flushing, decreased BP, GI ulceration/haemorrhage/nausea/vomiting, weakness. Serious ulcer complications (perforation, fistula, abscess) reported post-marketing.International label, same formulation · MHRA / emc

• Hypersensitivity to nicorandil or excipients; shock (including cardiogenic), severe hypotension, or LV dysfunction with low filling pressure/cardiac decompensation; PDE5 inhibitors; soluble guanylate cyclase stimulators (e.g. riociguat); hypovolaemia; acute pulmonary oedema.International label, same formulation · MHRA / emc

• GI, skin and mucosal ulcerations (discontinue if ulcers develop). Increased GI haemorrhage risk with aspirin/NSAIDs; perforation risk with corticosteroids. Eye ulcerations reported. Caution with other BP-lowering drugs; rare severe hyperkalaemia; caution in G6PD deficiency.International label, same formulation · MHRA / emc

• PDE5 inhibitors (sildenafil, tadalafil, vardenafil)MajorSerious drop in blood pressure; contraindicated.MHRA / emc
• NSAIDs / acetylsalicylic acid; corticosteroidsMajorIncreased risk of GI ulceration, perforation and haemorrhage.MHRA / emc

• Preferable to avoid use during pregnancy as a precaution; limited human data.International label, same formulation · MHRA / emc
• Not recommended during breastfeeding; excretion into human milk unknown.International label, same formulation · MHRA / emc

• Nicorandil: Dual action: opens ATP-sensitive potassium channels (arterial vasodilation, reduced afterload) and, through its nitrate moiety, increases cyclic GMP (venous relaxation, reduced preload); also dilates coronary arteries.