سعر ابيجنت 3 مجم/مل نقط 5 مل 2022

Apigent 3 mg/ml eye/ear drops (gentamicin), an aminoglycoside antibiotic solution for ophthalmic and otic use by Amoun; 5 ml bottle.

• Bacterial infections of the external eye and adnexa (conjunctivitis, keratitis, corneal ulcers, blepharitis, meibomianitis, episcleritis, dacryocystitis)Population: Adults, elderly and childrenelectronic medicines compendium (emc), UK
• Prevention of ocular infection after foreign-body removal, conjunctival burns or lacerations, chemical/physical damage and ocular surgeryPopulation: Adults, elderly and childrenelectronic medicines compendium (emc), UK
• Otitis externaPopulation: Adults, elderly and childrenelectronic medicines compendium (emc), UK

• Frequency unknown: local sensitivity, blurred vision, eye irritation, burning, stinging, itching; ototoxicity, vestibular disorder and hearing loss; skin burning, stinging, pruritus, dermatitis.International label, equivalent formulation · electronic medicines compendium (emc), UK
• US label: ocular burning and irritation, non-specific conjunctivitis, conjunctival epithelial defects and hyperaemia; bacterial and fungal corneal ulcers; rarely allergic reactions, thrombocytopenic purpura, hallucinations.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to gentamicin or excipients; known allergy to gentamicin or other aminoglycosides.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Myasthenia gravis and related conditions (neuromuscular blockade).International label, equivalent formulation · electronic medicines compendium (emc), UK
• Perforated tympanic membrane.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Avoid prolonged use (sensitisation, resistant organisms); cross-sensitivity with other aminoglycosides may occur; severe infections need supplementary systemic antibiotics.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Ototoxicity (vestibular damage, irreversible deafness) may occur with direct middle/inner ear contact or application to damaged skin; higher risk with renal/hepatic impairment, in the elderly and with mitochondrial mutations (m.1555A>G). Check ear-drum integrity before prescribing.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Contains benzalkonium chloride: may deposit in soft contact lenses and cause eye irritation/dry-eye symptoms; caution in dry eye or compromised cornea.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Potent diuretics (ethacrynic acid, furosemide)Believed to enhance the risk of ototoxicity.electronic medicines compendium (emc), UK
• Amphotericin B, cisplatin, ciclosporin, cephalosporinsPotential enhancers of nephrotoxicity; avoid concurrent nephrotoxic/ototoxic drugs unless essential.electronic medicines compendium (emc), UK
• Curare-type muscle relaxantsNeuromuscular blockade and respiratory paralysis reported with aminoglycosides during anaesthesia.electronic medicines compendium (emc), UK

• Safety in pregnancy has not been established; use only when considered essential by the physician after careful benefit-risk assessment.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Safety in lactation has not been established; use only when considered essential.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Gentamicin: Bactericidal; its most important effect is inhibition of bacterial protein synthesis at the level of the 30S ribosomal subunit; also affects plasma-membrane integrity and RNA metabolism (UK SmPC, gentamicin eye/ear drops).