سعر اوبتيجينت 0.3% قطرة للعين والأذن 2024

Gentamicin 0.3% eye/ear drops, 5 ml bottle.

• Infections of the external structures of the eye and adnexa (conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis, episcleritis, dacryocystitis); prevention of ocular infection after foreign-body removal, burns, lacerations or ocular surgery.Population: Adults, elderly and childrenelectronic medicines compendium (emc)
• Otitis externa.Population: Adults, elderly and childrenelectronic medicines compendium (emc)

• Frequency unknown: local sensitivity, blurred vision, eye irritation, burning, stinging, itching; ototoxicity, vestibular disorder, hearing loss (ear); dermatitis.International label, same formulation · electronic medicines compendium (emc)
• Most frequent: ocular burning and irritation, non-specific conjunctivitis, conjunctival epithelial defects and hyperaemia; rarely allergic reactions, thrombocytopenic purpura, hallucinations.International label, same formulation · DailyMed (NLM)

• Hypersensitivity to gentamicin, other aminoglycosides or excipients; myasthenia gravis and related conditions; perforated tympanic membrane.International label, same formulation · electronic medicines compendium (emc)

• Avoid prolonged use (sensitisation, resistant organisms); cross-sensitivity with other aminoglycosides may occur.International label, same formulation · electronic medicines compendium (emc)
• Irreversible ototoxicity may result from direct contact with the middle/inner ear; check the ear drum before otic use; higher risk with mitochondrial mutations (m.1555A>G).International label, same formulation · electronic medicines compendium (emc)
• UK product contains benzalkonium chloride: remove soft contact lenses and wait 15 minutes before reinsertion.International label, same formulation · electronic medicines compendium (emc)

• Potent diuretics (ethacrynic acid, furosemide)Believed to enhance any risk of ototoxicity.electronic medicines compendium (emc)
• Amphotericin B, cisplatin, ciclosporin, cephalosporinsPotential enhancers of nephrotoxicity; avoid concurrent nephrotoxic/ototoxic drugs unless essential.electronic medicines compendium (emc)
• Curare-type muscle relaxantsNeuromuscular blockade and respiratory paralysis reported with aminoglycosides.electronic medicines compendium (emc)

• Safety in pregnancy not established; use only when considered essential after careful risk-benefit assessment.International label, same formulation · electronic medicines compendium (emc)
• Safety in lactation not established; use only when considered essential.International label, same formulation · electronic medicines compendium (emc)

• Gentamicin: Bactericidal; mainly inhibits bacterial protein synthesis at the 30S ribosomal subunit and also affects plasma-membrane integrity and RNA metabolism.