سعر اوجمنتين اي اس-600 معلق 75 مل 600 مجم/42.9 مجم per 5 مل 2024

Augmentin ES-600 (amoxicillin 600 mg + clavulanic acid 42.9 mg per 5 ml, 14:1) powder for oral suspension, 75 ml; penicillin with beta-lactamase inhibitor.

• Recurrent or persistent acute otitis media due to S. pneumoniae (penicillin MIC 2 mcg/mL or less), H. influenzae or M. catarrhalis (including beta-lactamase-producing strains) in children 3 months to 12 years weighing 40 kg or less with risk factors (antibacterial exposure for acute otitis media in the preceding 3 months and either age 2 years or younger or day-care attendance); not indicated when S. pneumoniae penicillin MIC is 4 mcg/mL or more.Population: Pediatric patients 3 months to 12 years weighing 40 kg or lessDailyMed (U.S. National Library of Medicine)

• Clinical trials (children with acute otitis media): vomiting (7%), fever (6%), contact dermatitis/diaper rash (6%), upper respiratory tract infection (4%) and diarrhea (4%); protocol-defined diarrhea occurred in 11-13% of patients.International label, same product · DailyMed (U.S. National Library of Medicine)
• Postmarketing (Augmentin products): DIES, gastrointestinal effects, mucocutaneous candidiasis, hemorrhagic/pseudomembranous colitis; hypersensitivity reactions including anaphylaxis, angioedema, serum sickness-like reactions and vasculitis; rashes, erythema multiforme, SJS, TEN, DRESS, AGEP; hepatic, renal, hematologic and CNS effects.International label, same product · DailyMed (U.S. National Library of Medicine)

• History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins).International label, same product · DailyMed (U.S. National Library of Medicine)
• Previous history of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate.International label, same product · DailyMed (U.S. National Library of Medicine)

• Serious allergic reactions including anaphylaxis, severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) and drug-induced enterocolitis syndrome (DIES) may occur; discontinue and treat appropriately.International label, same product · DailyMed (U.S. National Library of Medicine)
• Use with caution in hepatic dysfunction; hepatic toxicity is usually reversible, but deaths have been reported (generally with serious underlying disease or concomitant medications).International label, same product · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhea may occur, including more than 2 months after treatment. Avoid in mononucleosis (erythematous rash); consider superinfection.International label, same product · DailyMed (U.S. National Library of Medicine)

• ProbenecidDecreases renal tubular secretion of amoxicillin, increasing and prolonging amoxicillin levels; co-administration is not recommended.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsIncreased INR/prolonged prothrombin time reported; monitor and adjust the anticoagulant dose if necessary.DailyMed (U.S. National Library of Medicine)
• AllopurinolConcurrent use with amoxicillin substantially increases the incidence of rashes (no data with ES-600).DailyMed (U.S. National Library of Medicine)

• Decades of published epidemiologic and pharmacovigilance data have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal outcomes; in women with preterm prelabor rupture of membranes (PPROM), prophylactic amoxicillin/clavulanate may be associated with an increased risk of necrotizing enterocolitis in neonates.International label, same product · DailyMed (U.S. National Library of Medicine)
• Amoxicillin is present in human milk; diarrhea, irritability and rash have been reported in breastfed infants exposed to amoxicillin/clavulanate - monitor the infant.International label, same product · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Bactericidal penicillin that inhibits bacterial cell-wall biosynthesis; susceptible to degradation by beta-lactamases, which clavulanic acid inhibits.
• Clavulanic acid: Beta-lactam structurally related to the penicillins that inactivates many beta-lactamase enzymes, protecting amoxicillin from degradation and extending its antibacterial spectrum.