سعر ميناليب بلس 10/40مجم 7 اقراص 2022

Ezetimibe 10 mg + simvastatin 40 mg tablets (Minalip plus; Alfacure Pharmaceuticals), pack of 7 tablets.

• As an adjunct to diet to reduce LDL-C in adults with primary hyperlipidaemia.Population: AdultsDailyMed (U.S. NLM)
• As an adjunct to diet to reduce LDL-C in adults and paediatric patients aged 10 years and older with heterozygous familial hypercholesterolaemia (HeFH).Population: Adults and children aged 10 years and olderDailyMed (U.S. NLM)
• As an adjunct to other LDL-C-lowering therapies to reduce LDL-C in adults with homozygous familial hypercholesterolaemia (HoFH).Population: AdultsDailyMed (U.S. NLM)

• Commonly reported adverse reactions include headache, increased ALT, myalgia, upper respiratory tract infection and diarrhoea.International label, same formulation · DailyMed (U.S. NLM)

• Concomitant use of strong CYP3A4 inhibitors.International label, same formulation · DailyMed (U.S. NLM)
• Concomitant use of cyclosporine, danazol or gemfibrozil.International label, same formulation · DailyMed (U.S. NLM)
• Acute liver failure or decompensated cirrhosis.International label, same formulation · DailyMed (U.S. NLM)

• Myopathy and rhabdomyolysis: risk increases with higher simvastatin doses, age 65 years or older, uncontrolled hypothyroidism, renal impairment and interacting drugs; discontinue if CK is markedly elevated or myopathy is suspected.International label, same formulation · DailyMed (U.S. NLM)
• Hepatic dysfunction: transaminase increases can occur; consider liver enzyme testing before starting and as clinically indicated.International label, same formulation · DailyMed (U.S. NLM)

• Verapamil, diltiazem, dronedaroneDo not exceed 10 mg/10 mg daily with these drugs.DailyMed (U.S. NLM)
• Amiodarone, amlodipine, ranolazineDo not exceed 10 mg/20 mg daily with these drugs.DailyMed (U.S. NLM)
• Strong CYP3A4 inhibitors; cyclosporine; danazol; gemfibrozilConcomitant use is contraindicated (markedly increased myopathy risk).DailyMed (U.S. NLM)

• Discontinue when pregnancy is recognised, or alternatively consider the ongoing therapeutic needs of the individual patient; may cause fetal harm based on its mechanism of action.International label, same formulation · DailyMed (U.S. NLM)
• Breastfeeding is not recommended during treatment (statins may pass into human milk).International label, same formulation · DailyMed (U.S. NLM)

• Ezetimibe: Inhibits intestinal absorption of cholesterol and related phytosterols.
• Simvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme of hepatic cholesterol synthesis, lowering LDL-C.