سعر ليبيدنورم كو 10/10 مجم 10 اقراص 2022

Fixed-dose combination of ezetimibe 10 mg and simvastatin 10 mg film-coated tablets used with diet to lower LDL cholesterol.

• Adjunct to diet to reduce elevated LDL-C in adults with primary hyperlipidemia.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce elevated LDL-C in adults and children aged 10 years and older with HeFH.Population: Adults and children >= 10 yearsDailyMed (U.S. National Library of Medicine)
• Adjunct to other LDL-C-lowering therapies to reduce elevated LDL-C in adults with HoFH.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most commonly reported adverse reactions (>= 2% and greater than placebo): headache (5.8%), increased ALT (3.7%), myalgia (3.6%), upper respiratory tract infection (3.6%) and diarrhoea (2.8%).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use of strong CYP3A4 inhibitors (certain azole antifungals, macrolide antibiotics, antivirals and nefazodone).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant use of gemfibrozil, cyclosporine or danazol.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Acute liver failure or decompensated cirrhosis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk is dose-related and higher with the 10/80 mg dose, age 65 or older, uncontrolled hypothyroidism, renal impairment and interacting drugs; discontinue if myopathy is suspected or CK is markedly elevated.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Immune-mediated necrotizing myopathy has been reported rarely; discontinue if suspected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction: transaminase elevations have been reported; consider liver enzyme testing before starting and when clinically indicated.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, clarithromycin, HIV protease inhibitors, nefazodone)Markedly increase simvastatin exposure and myopathy risk; contraindicated.DailyMed (U.S. National Library of Medicine)
• Gemfibrozil, cyclosporine, danazolIncreased risk of myopathy/rhabdomyolysis; contraindicated.DailyMed (U.S. National Library of Medicine)
• Verapamil, diltiazem, dronedaroneIncrease simvastatin exposure; do not exceed 10/10 mg once daily.DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognised (or consider the ongoing therapeutic need); may cause fetal harm based on the mechanism of the statin component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Ezetimibe: Inhibits intestinal absorption of cholesterol and phytosterols by targeting the NPC1L1 sterol transporter at the small-intestinal brush border (US VYTORIN label).
• Simvastatin: Prodrug hydrolysed to its active beta-hydroxyacid, which inhibits HMG-CoA reductase and reduces cholesterol synthesis (US VYTORIN label).