سعر ليبيكونترول 80/10مجم 20 قرص 2024

Fixed-dose combination of ezetimibe 10 mg and atorvastatin 80 mg oral tablets used with diet to lower LDL cholesterol.

• Reduction of elevated total-C, LDL-C, Apo B, TG and non-HDL-C, and increase of HDL-C, in primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia, as an adjunct to diet.Population: Patients with primary or mixed hyperlipidemiaDailyMed (U.S. National Library of Medicine)
• Reduction of elevated total-C and LDL-C in homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g. LDL apheresis) or if such treatments are unavailable.Population: Patients with HoFHDailyMed (U.S. National Library of Medicine)

• Most commonly reported adverse reactions (>= 2% and greater than placebo) in the placebo-controlled trial: increased ALT, increased AST and musculoskeletal pain.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Active liver disease or unexplained persistent elevations of hepatic transaminase levels.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to any component of the product.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Women who are pregnant or may become pregnant.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy/rhabdomyolysis: rare rhabdomyolysis with acute renal failure has been reported with atorvastatin; risk increases with renal impairment and certain interacting drugs; discontinue if CK is markedly elevated or myopathy is suspected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Liver enzyme abnormalities: persistent transaminase elevations can occur; perform liver enzyme tests before starting and when clinically indicated.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Cyclosporine; tipranavir plus ritonavir; telaprevirAvoid concomitant therapy.DailyMed (U.S. National Library of Medicine)
• Clarithromycin, itraconazole, saquinavir/ritonavir, darunavir/ritonavir, fosamprenavir (+/- ritonavir), elbasvir/grazoprevirIncrease atorvastatin exposure; limit to 10/20 mg daily and use the lowest dose necessary.DailyMed (U.S. National Library of Medicine)
• Nelfinavir; boceprevirLimit to 10/40 mg daily.DailyMed (U.S. National Library of Medicine)

• Contraindicated in women who are pregnant or may become pregnant; may cause fetal harm. If pregnancy occurs during treatment, discontinue and inform the patient of the potential hazard to the fetus.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Nursing mothers should not take this combination because of the potential for adverse reactions in nursing infants.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Ezetimibe: Inhibits intestinal absorption of cholesterol and phytosterols by targeting the NPC1L1 sterol transporter at the small-intestinal brush border (US VYTORIN label).
• Atorvastatin: Selective, competitive inhibitor of HMG-CoA reductase; lowers hepatic cholesterol synthesis and increases hepatic LDL receptors, enhancing LDL uptake (US LIPITOR label).