سعر بيسولوك Bisolock‏ 10مجم 30 قرص 2026

Bisolock 10Mg 30 F.C.Tab (30 film-coated tablets), antihypertensive (beta-1-selective blocker) marketed in Egypt by Pharco.

• Very common: bradycardia (heart failure). Common: dizziness, headache, worsening heart failure, cold extremities, hypotension, GI complaints (nausea, vomiting, diarrhoea, constipation), fatigue/asthenia. Uncommon: sleep disorders, depression, AV-conduction disturbances, bronchospasm, muscle weakness and cramps. Rare: nightmares, hallucinations, syncope, reduced tear flow, hearing disorders, allergic rhinitis, hepatitis, hypersensitivity reactions, potency disorders, raised triglycerides and liver enzymes.International label, same formulation · Medicines and Healthcare products Regulatory Agency (MHRA) / electronic medicines compendium (emc), UK

• Acute heart failure or decompensation requiring IV inotropes; cardiogenic shock; second/third-degree AV block without pacemaker; sick sinus syndrome; sinoatrial block; symptomatic bradycardia or hypotension; severe bronchial asthma or severe COPD; late-stage peripheral arterial occlusive disease and Raynaud's syndrome; untreated phaeochromocytoma; metabolic acidosis; hypersensitivity.International label, same formulation · Medicines and Healthcare products Regulatory Agency (MHRA) / electronic medicines compendium (emc), UK

• Do not stop abruptly, especially in ischaemic heart disease. Caution in bronchospasm/asthma, diabetes with fluctuating glucose (masked hypoglycaemia; sulfonylurea risk), strict fasting, desensitisation therapy (increased anaphylaxis severity), first-degree AV block, Prinzmetal angina, peripheral arterial disease, general anaesthesia, psoriasis; phaeochromocytoma only after alpha-blockade; may mask thyrotoxicosis.International label, same formulation · Medicines and Healthcare products Regulatory Agency (MHRA) / electronic medicines compendium (emc), UK

• Verapamil- and diltiazem-type calcium antagonistsNegative effect on contractility and AV conduction; IV verapamil may cause profound hypotension and AV block (not recommended).Medicines and Healthcare products Regulatory Agency (MHRA) / electronic medicines compendium (emc), UK
• Centrally acting antihypertensives (clonidine, methyldopa, moxonidine, rilmenidine)May worsen heart failure; abrupt withdrawal may cause rebound hypertension (not recommended).Medicines and Healthcare products Regulatory Agency (MHRA) / electronic medicines compendium (emc), UK
• Class I and class III antiarrhythmicsPotentiated AV conduction time and negative inotropy.Medicines and Healthcare products Regulatory Agency (MHRA) / electronic medicines compendium (emc), UK

• Beta-blockers reduce placental perfusion (growth retardation, intrauterine death, abortion, early labour) and may cause fetal/neonatal hypoglycaemia and bradycardia; use only if clearly necessary with monitoring of uteroplacental flow and fetal growth; monitor the newborn closely.International label, same formulation · Medicines and Healthcare products Regulatory Agency (MHRA) / electronic medicines compendium (emc), UK
• Unknown whether excreted in human milk; breastfeeding not recommended.International label, same formulation · Medicines and Healthcare products Regulatory Agency (MHRA) / electronic medicines compendium (emc), UK

• Bisoprolol fumarate: Highly beta-1-selective adrenoceptor blocker without intrinsic sympathomimetic or relevant membrane-stabilising activity; reduces heart rate, contractility and sympathetic drive.