سعر سوبرول 5مجم 20 اقراص 2022

Bisoprolol fumarate 5 mg film-coated tablets, pack of 20 (2 strips); EVA Pharma, Egypt.

• Management of hypertension, alone or in combination with other antihypertensive agents.Population: AdultsDailyMed (U.S. NLM)

• Adverse events in US trials included fatigue, dizziness, headache, diarrhoea and upper respiratory symptoms; bradycardia, diarrhoea, asthenia, fatigue and sinusitis appeared dose related.International label, equivalent formulation · DailyMed (U.S. NLM)

• Cardiogenic shock, overt cardiac failure, second- or third-degree AV block, and marked sinus bradycardia.International label, equivalent formulation · DailyMed (U.S. NLM)

• Do not stop abruptly: exacerbation of angina, myocardial infarction or ventricular arrhythmia may follow; taper over about one week.International label, equivalent formulation · DailyMed (U.S. NLM)
• Use cautiously in compensated heart failure, peripheral vascular disease and bronchospastic disease (lowest dose, starting at 2.5 mg, with a beta2 agonist available).International label, equivalent formulation · DailyMed (U.S. NLM)
• May mask signs of hypoglycaemia (tachycardia) and of hyperthyroidism; abrupt withdrawal may precipitate thyroid storm; patients with a history of severe anaphylaxis may be more reactive and less responsive to epinephrine.International label, equivalent formulation · DailyMed (U.S. NLM)

• Other beta-blocking agentsShould not be combined.DailyMed (U.S. NLM)
• Catecholamine-depleting drugs (reserpine, guanethidine)Monitor closely for excessive reduction of sympathetic activity.DailyMed (U.S. NLM)
• ClonidineIf discontinuing, stop bisoprolol several days before clonidine withdrawal.DailyMed (U.S. NLM)

• No adequate and well-controlled studies in pregnant women; use only if the potential benefit justifies the potential risk to the fetus (fetotoxicity seen in rats at high doses).International label, equivalent formulation · DailyMed (U.S. NLM)
• Not known whether excreted in human milk (small amounts in rat milk); use with caution in nursing women.International label, equivalent formulation · DailyMed (U.S. NLM)

• Bisoprolol fumarate: Beta-1-selective adrenoceptor blocker without significant intrinsic sympathomimetic activity; lowers heart rate and cardiac output.