سعر كالسيفولينون Calcifolinon‏ 100مجم/10مل فيال 2026

Calcifolinon 100 mg/10 ml (calcium folinate, leucovorin) vial for IM/IV injection or infusion, marketed in Egypt by Global Pharmaceutical Industries.

• Allergic sensitization including anaphylactoid reactions, urticaria and anaphylactic shock has been reported; no other adverse reactions are attributed to leucovorin itself. With fluorouracil, leukopenia, nausea, vomiting, diarrhea, stomatitis and alopecia are common.International label, same formulation · U.S. National Library of Medicine DailyMed (FDA SPL)

• Improper therapy for pernicious anemia and other megaloblastic anemias secondary to vitamin B12 deficiency: hematologic remission may occur while neurologic manifestations progress.International label, same formulation · U.S. National Library of Medicine DailyMed (FDA SPL)

• Do not administer intrathecally; leucovorin may be harmful or fatal if given intrathecally.International label, same formulation · U.S. National Library of Medicine DailyMed (FDA SPL)
• Because of the calcium content, inject no more than 160 mg of leucovorin intravenously per minute (16 mL of a 10 mg/mL solution per minute).International label, same formulation · U.S. National Library of Medicine DailyMed (FDA SPL)
• In antifolate overdose give leucovorin as promptly as possible; effectiveness decreases as the interval after the antifolate increases.International label, same formulation · U.S. National Library of Medicine DailyMed (FDA SPL)

• Phenobarbital, phenytoin, primidoneFolic acid in large amounts may counteract their antiepileptic effect and increase seizure frequency in susceptible children.U.S. National Library of Medicine DailyMed (FDA SPL)
• Intrathecal methotrexateHigh doses of leucovorin may reduce the efficacy of intrathecally administered methotrexate.U.S. National Library of Medicine DailyMed (FDA SPL)
• FluorouracilLeucovorin enhances fluorouracil toxicity.U.S. National Library of Medicine DailyMed (FDA SPL)

• Adequate animal reproduction studies have not been conducted; unknown whether it causes fetal harm. Give to a pregnant woman only if clearly needed.International label, same formulation · U.S. National Library of Medicine DailyMed (FDA SPL)
• Unknown whether excreted in human milk; use caution in nursing mothers.International label, same formulation · U.S. National Library of Medicine DailyMed (FDA SPL)

• Calcium folinate: Reduced folate that does not need dihydrofolate reductase; bypasses methotrexate blockade and stabilises fluorouracil binding to thymidylate synthase.