سعر كانديبلوك-د 16/12.5 مجم 20 قرص 2024

Candesartan cilexetil + hydrochlorothiazide 16/12.5 mg, 20 tablets (Pharco).

• Treatment of hypertension in adults and children 1 to <17 years of age, to lower blood pressure (US ATACAND label).Population: Adults and children 1 to <17 years (US label)DailyMed / FDA
• Treatment of heart failure (NYHA class II–IV); reduces cardiovascular death and heart failure hospitalization (US ATACAND).Population: Adults with heart failure (US label)DailyMed / FDA
• Essential hypertension in adults; hypertension in children/adolescents 6 to <18 years; heart failure with LVEF ≤40% when ACE inhibitors not tolerated or as add-on (UK Amias SmPC).Population: Per UK SmPC populationsMedicines.org.uk (eMC / MHRA)

• Most common adverse reactions leading to discontinuation in hypertension: headache (0.6%) and dizziness (0.3%) (US ATACAND).International label, same formulation · DailyMed / FDA

• Known hypersensitivity to product components. Do not co-administer aliskiren with candesartan in patients with diabetes (US ATACAND).International label, same formulation · DailyMed / FDA
• Hypersensitivity to candesartan cilexetil or excipients; second and third trimesters of pregnancy; severe hepatic impairment and/or cholestasis; children aged below 1 year; concomitant aliskiren in diabetes or renal impairment GFR <60 (UK Amias).International label, same formulation · Medicines.org.uk (eMC / MHRA)

• BOXED WARNING — Fetal toxicity: when pregnancy is detected, discontinue as soon as possible. Drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus (US ATACAND).International label, same formulation · DailyMed / FDA
• Observe for hypotension; monitor renal function and potassium (US ATACAND).International label, same formulation · DailyMed / FDA

• AliskirenMajorDo not co-administer aliskiren with candesartan in patients with diabetes (US); contraindicated with aliskiren in diabetes or renal impairment GFR <60 (UK).DailyMed / FDA, Medicines.org.uk (eMC / MHRA)
• Potassium-sparing diuretics / potassium supplements / salt substitutesModerateMonitor serum potassium; ARBs may increase potassium (ingredient-level / US warnings).DailyMed / FDA

• When pregnancy is detected, discontinue candesartan as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (US ATACAND boxed warning / PLLR context).International label, same formulation · DailyMed / FDA

• Candesartan cilexetil: Prodrug hydrolysed to candesartan during absorption; candesartan selectively blocks angiotensin II binding to the AT1 receptor.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.