سعر ساركوزيد 16/12.5مجم 20 قرص 2024

Sarcozide 16/12.5 mg tablets (candesartan cilexetil 16 mg + hydrochlorothiazide 12.5 mg), pack of 20, by October Pharma (Egypt); fixed-dose angiotensin II receptor blocker/thiazide diuretic combination.

• Hypertension, to lower blood pressure (not indicated for initial therapy).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Controlled trials (>2% and more than placebo): upper respiratory tract infection, back pain, influenza-like symptoms, dizziness.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Candesartan post-marketing (very rare): hepatitis/abnormal liver function, neutropenia, leukopenia, agranulocytosis, angioedema, hyperkalaemia, hyponatraemia, cough, pruritus, rash, urticaria. Hydrochlorothiazide: pancreatitis, cholestatic jaundice, blood dyscrasias, photosensitivity, anaphylaxis, Stevens-Johnson syndrome/toxic epidermal necrolysis, blurred vision, impotence, non-melanoma skin cancer.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to candesartan, hydrochlorothiazide or other sulfonamide-derived drugs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Co-administration with aliskiren in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anuria.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity: discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension in volume- or salt-depleted patients (correct before starting); in heart failure start under close supervision.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Impaired renal function, including acute renal failure; monitor renal function periodically.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• NSAIDs including selective COX-2 inhibitorsMay worsen renal function (possible acute renal failure) in elderly, volume-depleted or renally impaired patients and attenuate the antihypertensive effect; monitor renal function.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium and toxicity with angiotensin II antagonists or hydrochlorothiazide; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• ACE inhibitors, angiotensin receptor blockers or aliskiren (dual RAS blockade)Increased hypotension, hyperkalaemia and renal function changes; do not use aliskiren in diabetes and avoid in GFR <60 mL/min.DailyMed (U.S. National Library of Medicine)

• Boxed warning: fetal toxicity. Drugs acting on the renin-angiotensin system during the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Thiazides appear in human milk and candesartan is present in rat milk; decide whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Candesartan cilexetil: Prodrug hydrolysed to candesartan during absorption; candesartan selectively blocks angiotensin II binding to the AT1 receptor.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.