سعر كابوتين Capoten‏ 25مجم 20 قرص 2026

Capoten 25 mg tablets (captopril 25 mg), pack of 20 tablets, marketed in Egypt (smithkline beecham).

• Rash (about 4-7 per 100 patients, often with pruritus), taste disturbance, cough, proteinuria (about 1 per 100), neutropenia/agranulocytosis, hypotension.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to captopril or any ACE inhibitor (e.g. prior ACE-inhibitor angioedema); with aliskiren in diabetes; with a neprilysin inhibitor (sacubitril) or within 36 hours of switching to/from sacubitril/valsartan.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity: drugs acting on the renin-angiotensin system can injure or kill the developing fetus; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Angioedema of face, lips, tongue, glottis or larynx may occur and can be fatal; neutropenia/agranulocytosis (higher risk with renal impairment or collagen vascular disease); proteinuria; hypotension in salt/volume-depleted patients; persistent dry cough.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potassium-sparing diuretics / potassium supplementsRisk of hyperkalaemia.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium and lithium toxicity.DailyMed (U.S. National Library of Medicine)
• Sacubitril (neprilysin inhibitor)Angioedema risk; contraindicated, 36-hour washout.DailyMed (U.S. National Library of Medicine)

• Boxed warning: when used in the second and third trimesters ACE inhibitors can cause injury and death to the fetus; stop as soon as possible once pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Captopril concentrations in human milk are about 1% of maternal blood levels; decide whether to stop nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Captopril: Competitively inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion and decreasing bradykinin breakdown.