سعر فاركوبريل 50 مجم 20 قرص 2022

Captopril 50 mg tablets (angiotensin-converting enzyme inhibitor), pack of 20.

• Hypertension.DailyMed (U.S. National Library of Medicine)
• Congestive heart failure, usually in combination with diuretics and digitalis.DailyMed (U.S. National Library of Medicine)
• Improving survival after myocardial infarction in clinically stable patients with left ventricular dysfunction (ejection fraction <=40%).DailyMed (U.S. National Library of Medicine)

• Rash (often with pruritus) in about 4-7 per 100 patients, pruritus without rash ~2/100, proteinuria ~1/100; taste alteration, hypotension, cough; neutropenia/agranulocytosis, anaemia, thrombocytopenia and angioedema reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to captopril or any other ACE inhibitor (e.g. angioedema with a previous ACE inhibitor); co-administration with aliskiren in patients with diabetes; combination with a neprilysin inhibitor (e.g. sacubitril) - do not give within 36 hours of switching to or from sacubitril/valsartan.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: discontinue as soon as pregnancy is detected; drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Head/neck and intestinal angioedema (possible fatal airway obstruction); neutropenia/agranulocytosis (higher risk with renal impairment or collagen vascular disease); hypotension (especially with diuretics or salt/volume depletion); proteinuria; hyperkalaemia; persistent non-productive cough; dual RAS blockade increases hypotension, hyperkalaemia and renal failure risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• LithiumIncreased serum lithium levels and lithium toxicity reported; co-administer with caution and monitor lithium levels frequently.DailyMed (U.S. National Library of Medicine)
• Potassium-sparing diuretics (spironolactone, triamterene, amiloride), potassium supplements, potassium-containing salt substitutesMay significantly increase serum potassium; use only for documented hypokalaemia and with caution.DailyMed (U.S. National Library of Medicine)
• Aliskiren / angiotensin receptor blockers / other ACE inhibitors (dual RAS blockade)Increased risk of hypotension, hyperkalaemia and renal function changes; avoid combined use; do not co-administer aliskiren in diabetes.DailyMed (U.S. National Library of Medicine)

• Drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as possible when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Captopril concentrations in human milk are about 1% of maternal blood levels; because of potential serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Captopril: Competitively inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion and decreasing bradykinin breakdown.