سعر كير ديبين 10 مجم 20 قرص مغلف 2026

Care Dipine 10 mg film-coated tablets (Misr > Pharmacare); lercanidipine selective calcium channel blocker for hypertension.

• Treatment of mild to moderate essential hypertension in adults.Population: AdultsMHRA / emc

• Most commonly reported: peripheral oedema, headache, flushing, tachycardia and palpitations. Other reactions include dizziness, hypotension, GI symptoms, rash, polyuria; rare angina; post-marketing gingival hypertrophy, angioedema, cloudy peritoneal effluent.International label, equivalent formulation · MHRA / emc

• Hypersensitivity to lercanidipine or excipients; left ventricular outflow tract obstruction; untreated congestive cardiac failure; unstable angina or recent MI (within 1 month); severe hepatic impairment; severe renal impairment (GFR <30) including dialysis; co-administration with strong CYP3A4 inhibitors, ciclosporin, or grapefruit/grapefruit juice.International label, equivalent formulation · MHRA / emc

• Caution in sick sinus syndrome without pacemaker, left ventricular dysfunction, and ischaemic heart disease. Alcohol may potentiate vasodilating effects. Contains lactose.International label, equivalent formulation · MHRA / emc

• Strong CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin, erythromycin)MajorContraindicated: substantial increase in lercanidipine exposure.MHRA / emc
• CiclosporinMajorContraindicated: mutual increase in plasma levels.MHRA / emc
• Grapefruit / grapefruit juiceMajorContraindicated: increases systemic availability and hypotensive effect.MHRA / emc

• No data from use in pregnant women. Animal studies have not shown teratogenic effects, but teratogenicity observed with other dihydropyridines. Not recommended during pregnancy or in women of childbearing potential not using contraception.International label, equivalent formulation · MHRA / emc
• Unknown whether lercanidipine/metabolites are excreted in human milk; risk to newborns/infants cannot be excluded. Should not be used during breast-feeding.International label, equivalent formulation · MHRA / emc

• Lercanidipine: Inhibits extracellular calcium influx across vascular smooth muscle cell membranes, causing arterial vasodilation and reduced peripheral resistance.