سعر كلاويدول 50 مجم 30 قرص 2022

Claudol 50 mg tablets, 30 tablets (cilostazol). Delta Pharma / Activa Therapeutics. PDE3 inhibitor; 50 mg strength is also the US dose-reduction strength with CYP inhibitors.

• Reduction of symptoms of intermittent claudication, as demonstrated by increased walking distance (US cilostazol labeling).Population: Adults with intermittent claudicationDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (≥2% and ≥2× placebo at 100 mg BID): headache, diarrhea, abnormal stools, palpitation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Heart failure of any severity (boxed warning: PDE III inhibitors associated with decreased survival in class III–IV HF); hypersensitivity to cilostazol or components.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• May induce tachycardia, palpitation, tachyarrhythmia or hypotension; risk of angina/MI exacerbation in ischemic heart disease. Monitor CBC for thrombocytopenia/leukopenia. Avoid in hemostatic disorders or active pathologic bleeding.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Strong/moderate CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, diltiazem) or CYP2C19 inhibitors (e.g., omeprazole)MajorIncrease cilostazol exposure; reduce dose to 50 mg twice daily.DailyMed (U.S. National Library of Medicine)

• US label (historical Pregnancy Category C): teratogenic in animals at exposures above MRHD; no adequate well-controlled studies in pregnant women.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Excreted in rat milk; discontinue nursing or discontinue drug because of potential serious adverse reactions in nursing infants.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Cilostazol: Selective PDE3 inhibitor increasing cAMP; inhibits platelet aggregation and dilates arteries.