سعر كوفابريندو 10/10 مجم 30 قرص 2024

Covaprendo 10/10mg 30 tabs.: Perindopril+amlodipine (Global napi pharmaceuticals).

• Treatment of hypertension to lower blood pressure (perindopril + amlodipine). Lowering BP reduces risk of fatal and nonfatal cardiovascular events.Population: Adults with hypertension (and CAD where labelled)DailyMed (U.S. National Library of Medicine)

• History of angioedema or hypersensitivity to any ACE inhibitor or to amlodipine; do not use aliskiren with Prestalia in diabetes; do not take a neprilysin inhibitor (e.g. sacubitril) with Prestalia (36-hour separation). Fetal toxicity boxed warning for ACE inhibitors.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• ACE inhibitors: angioedema, hyperkalaemia, renal impairment risk; dual blockade with ARB/aliskiren not recommended. Amlodipine: worsening angina/AMI possible after starting or increasing dose; caution in severe hepatic impairment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• AliskirenMajorContraindicated/avoid with ACE inhibitor in diabetes or renal impairment.DailyMed (U.S. National Library of Medicine)
• Potassium-sparing diuretics / potassium supplementsMajorHyperkalaemia risk with ACE inhibitors; monitor.DailyMed (U.S. National Library of Medicine)
• NSAIDsModerateMay attenuate antihypertensive effect and worsen renal function.DailyMed (U.S. National Library of Medicine)

• ACE inhibitors are contraindicated in the second and third trimesters of pregnancy due to fetal toxicity. Discontinue when pregnancy is detected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Perindopril: Prodrug converted to perindoprilat; inhibits ACE reducing angiotensin II and aldosterone, lowering peripheral resistance.
• Amlodipine: Inhibits L-type calcium channels in vascular smooth muscle causing peripheral arterial vasodilation.