سعر كوفرسيل بلس 10/2.5 مجم 15 قرص 2024

Coversyl Plus 10/2.5 mg tablets (perindopril/indapamide), 15 tablets (Servier, Egypt).

• Essential hypertension in patients already controlled on perindopril and indapamide given concurrently at the same dose levels (substitution), or as step-up when monotherapy insufficient (per regional labels for perindopril/indapamide FCCs).Population: AdultsMHRA / eMC

• Hypotension, cough, dizziness, headache, electrolyte disturbances (especially potassium), rash, muscle cramps, asthenia; rare angioedema.International label, equivalent formulation · MHRA / eMC

• Hypersensitivity to perindopril, other ACE inhibitors, indapamide, sulphonamides, or excipients; angioedema history; severe renal impairment; hepatic encephalopathy; hypokalaemia; 2nd/3rd trimester pregnancy; aliskiren in diabetes/renal impairment; sacubitril/valsartan within 36 h.International label, equivalent formulation · MHRA / eMC

• ACE-inhibitor angioedema, cough, hyperkalaemia/hypokalaemia balance with indapamide, renal function monitoring, photosensitivity (indapamide), lithium interaction, dual RAAS blockade caution.International label, equivalent formulation · MHRA / eMC

• LithiumMajorIncreased lithium toxicity risk with ACE inhibitor ± diuretic.MHRA / eMC
• Potassium-sparing agents / NSAIDsModerateElectrolyte and renal effects; monitor.MHRA / eMC

• Contraindicated in 2nd/3rd trimester (ACE inhibitor + thiazide-like diuretic); not recommended in pregnancy or lactation.International label, equivalent formulation · MHRA / eMC

• Perindopril: Inhibits angiotensin-converting enzyme, reducing conversion of angiotensin I to the vasoconstrictor angiotensin II and the degradation of bradykinin.
• Indapamide: Inhibits sodium reabsorption in the cortical diluting segment, increasing urinary sodium and chloride excretion.