سعر كوزار 100 مجم 14 قرص مغلف 2024

Cozaar 100 mg losartan potassium film-coated tablets, 14 tablets (MSD / Global Napi, Egypt).

• Hypertension in adults and children ≥6 years to lower blood pressure.Population: Adults; pediatrics ≥6 yearsDailyMed / FDA
• Reduce risk of stroke in patients with hypertension and left ventricular hypertrophy (benefit not shown in Black patients).Population: Adults with HTN + LVHDailyMed / FDA
• Diabetic nephropathy with elevated serum creatinine and proteinuria in type 2 diabetes with hypertension history.Population: Adults with T2DM nephropathyDailyMed / FDA

• Hypertension trials (≥2% and >placebo): dizziness, upper respiratory infection, nasal congestion, back pain. Diabetic nephropathy: asthenia/fatigue, chest pain, hypotension, diarrhoea, anemia, hyperkalaemia, hypoglycemia, back pain, muscular weakness, UTI.International label, same product · DailyMed / FDA

• Hypersensitivity to any component; coadministration with aliskiren in patients with diabetes.International label, same product · DailyMed / FDA

• BOXED WARNING — fetal toxicity: discontinue when pregnancy detected. Hypotension in volume/salt depletion. Monitor renal function and potassium; risk of acute renal failure in susceptible patients. Hyperkalaemia.International label, same product · DailyMed / FDA

• Agents increasing serum potassiumMajorRisk of hyperkalaemia; monitor potassium.DailyMed / FDA
• LithiumMajorRisk of lithium toxicity; monitor levels.DailyMed / FDA
• NSAIDs including COX-2 inhibitorsModerateMay worsen renal function and attenuate antihypertensive effect.DailyMed / FDA

• Can cause fetal harm; drugs acting on RAS in 2nd/3rd trimester reduce fetal renal function and increase fetal/neonatal morbidity and death. Discontinue when pregnancy detected.International label, same product · DailyMed / FDA
• Unknown if excreted in human milk; present in rat milk. Decide whether to discontinue nursing or the drug.International label, same product · DailyMed / FDA

• Losartan potassium: Losartan and its principal active metabolite selectively block binding of angiotensin II to the AT1 receptor, blocking its vasoconstrictor and aldosterone-secreting effects (US label).