سعر دونيفوكسيت 40 مجم 30 قرص مغلف 2023

Egyptian febuxostat 40 mg film-coated tablets (30), Eva Pharma, for hyperuricaemia/gout.

• Chronic management of hyperuricemia in adults with gout who have an inadequate response to maximally titrated allopurinol, are intolerant to allopurinol, or for whom allopurinol is not advisable. Not for asymptomatic hyperuricemia.Population: Adults with goutDailyMed / FDA

• Common (≥1%): liver function abnormalities, nausea, arthralgia, rash.International label, same formulation · DailyMed / FDA

• Contraindicated in patients being treated with azathioprine or mercaptopurine.International label, same formulation · DailyMed / FDA

• Boxed warning: higher rate of CV death vs allopurinol in gout patients with established CV disease (CARES). Use only when allopurinol inadequate/intolerant/not advisable. Gout flares common after initiation. Hepatic failure (some fatal) reported. Serious skin reactions (SJS/DRESS/TEN) reported.International label, same formulation · DailyMed / FDA

• Azathioprine / mercaptopurineMajorXO inhibition increases plasma concentrations of these drugs → severe toxicity; contraindicated.DailyMed / FDA

• Limited human data insufficient to inform drug-associated risk; animal studies at high exposures did not show adverse developmental effects at multiples of MRHD (see US label).International label, same formulation · DailyMed / FDA
• Unknown whether febuxostat is present in human milk; present in rat milk. Weigh benefits of breastfeeding vs maternal need and potential infant effects.International label, same formulation · DailyMed / FDA

• Febuxostat: 2-arylthiazole derivative that lowers serum uric acid by potent, selective, non-purine inhibition of xanthine oxidase (oxidised and reduced forms), which catalyses hypoxanthine to xanthine to uric acid (EU SmPC).