سعر Feburic 40 mg 10 f.c. tablets 2026

Febuxostat 40 mg film-coated tablets (Hikma Pharma), 10 film-coated tablets per pack.

• Chronic management of hyperuricemia in adult patients with gout who have an inadequate response to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom allopurinol is not advisable; not recommended for asymptomatic hyperuricemia.Population: AdultsDailyMed (U.S. National Library of Medicine)

• US controlled trials (40 mg / 80 mg): liver function abnormalities 6.6% / 4.6%, nausea 1.1% / 1.3%, arthralgia 1.1% / 0.7%, rash 0.5% / 1.6%.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• US: contraindicated in patients being treated with azathioprine or mercaptopurine.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• US boxed warning: gout patients with established cardiovascular disease treated with ULORIC had a higher rate of CV death than with allopurinol; reserve for patients with inadequate response to, intolerance of, or unsuitability for allopurinol.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• US: fatal and nonfatal hepatic failure reported; obtain liver tests before starting and as clinically indicated. Serious skin and hypersensitivity reactions (SJS, DRESS, TEN) reported; discontinue if suspected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Azathioprine, mercaptopurineUS: concomitant use contraindicated (increased exposure may lead to toxicity).DailyMed (U.S. National Library of Medicine)
• TheophyllineUS: febuxostat altered theophylline metabolism in an interaction study; use with caution when coadministered.DailyMed (U.S. National Library of Medicine)

• US: limited data are insufficient to inform a drug-associated risk; no adverse developmental effects in rats and rabbits at exposures up to 40 and 51 times the maximum human exposure.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• US: no human data; febuxostat is present in rat milk; weigh benefits of breastfeeding against the mother's need for the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Febuxostat: Potent non-purine selective inhibitor of xanthine oxidase, reducing serum uric acid.