سعر داونستيرولين 10/40 مجم 28 قرص 2024

Downsterolin 10/40 mg film-coated tablets (ezetimibe 10 mg + simvastatin 40 mg), Medizen/Utopia, Egypt.

• As adjunct to diet for primary hyperlipidemia / mixed hyperlipidemia when ezetimibe + simvastatin combination is appropriate; reduce elevated total-C, LDL-C, Apo B, TG and increase HDL-C.Population: AdultsDailyMed / FDA

• Headache, myalgia, increased liver enzymes, upper respiratory infection, diarrhea; rare myopathy/rhabdomyolysis.International label, same formulation · DailyMed / FDA

• Active liver disease or unexplained persistent elevations of hepatic transaminases; concomitant strong CYP3A4 inhibitors / gemfibrozil / cyclosporine / danazol as listed for simvastatin; hypersensitivity; pregnancy and lactation for statin component.International label, same formulation · DailyMed / FDA

• Myopathy/rhabdomyolysis risk with simvastatin increases with dose and interacting drugs; monitor CK and muscle symptoms. Monitor liver enzymes.International label, same formulation · DailyMed / FDA

• Strong CYP3A4 inhibitors (e.g. itraconazole, clarithromycin, ritonavir)MajorStrong CYP3A4 inhibitors (e.g. itraconazole, clarithromycin, ritonavir): contraindicated / avoid with simvastatin.DailyMed / FDA
• Amiodarone, amlodipine, diltiazem, verapamilModerateAmiodarone, amlodipine, diltiazem, verapamil: limit simvastatin dose per label.DailyMed / FDA

• Contraindicated in pregnancy: cholesterol biosynthesis is essential for fetal development; discontinue if pregnancy occurs.International label, same formulation · DailyMed / FDA
• Not recommended during breastfeeding due to statin component.International label, same formulation · DailyMed / FDA

• Ezetimibe: Inhibits intestinal absorption of cholesterol and related phytosterols (US Vytorin label).
• Simvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis (US Vytorin label).