سعر دوموزول 500مجم 20 قرص 2023

Dumozol 500 mg film-coated tablets (metronidazole 500 mg), Mina Pharm / Alpharma-Denmark, Egypt.

• Anaerobic bacterial infections and protozoal infections (e.g. trichomoniasis, amebiasis) when metronidazole is appropriate per labeling.Population: Adults / as labeledDailyMed / FDA

• Common: metallic taste, nausea, headache, dry mouth, dark urine; candidiasis; rare serious neurologic and hypersensitivity reactions.International label, same formulation · DailyMed / FDA

• Hypersensitivity to metronidazole or other nitroimidazoles; concomitant disulfiram (within 2 weeks); alcohol/propylene glycol during and for 3 days after; Cockayne syndrome; first trimester for trichomoniasis (US label).International label, same formulation · DailyMed / FDA

• US boxed warning: metronidazole has been shown to be carcinogenic in mice and rats; unnecessary use should be avoided. Neurologic adverse effects (convulsive seizures, peripheral neuropathy) — discontinue if abnormal neurologic signs. Severe hepatic impairment: reduce dose.International label, same formulation · DailyMed / FDA

• Alcohol / propylene glycolMajorAlcohol / propylene glycol: disulfiram-like reaction — avoid during therapy and 3 days after.DailyMed / FDA
• WarfarinMajorWarfarin: potentiates anticoagulant effect; monitor INR.DailyMed / FDA
• Lithium / busulfanModerateLithium / busulfan: may increase levels — monitor.DailyMed / FDA

• US label contraindicates first-trimester use for trichomoniasis; discuss risk/benefit for other indications. Avoid unnecessary use given carcinogenicity findings in animals.International label, same formulation · DailyMed / FDA
• Present in milk; US labels advise pump and discard for 48 hours after last dose when interrupting breastfeeding.International label, same formulation · DailyMed / FDA

• Metronidazole: After passive diffusion into susceptible anaerobes it is reduced intracellularly (via electron-transport proteins such as ferredoxin) to a short-lived nitroso free radical; the reduced drug and free radicals can interact with DNA, inhibiting DNA synthesis and causing DNA degradation and bacterial death; the precise mechanism is unclear (US label).