سعر فلاجيكيور 250مجم 20 قرص 2022

Flagicure 250 mg tablets (metronidazole 250 mg), Kahira Pharmaceuticals & Chemical Industries, Egypt.

• Symptomatic and asymptomatic trichomoniasis, acute intestinal amoebiasis (amoebic dysentery) and amoebic liver abscess, and serious infections caused by susceptible anaerobic bacteria (intra-abdominal, skin, gynaecological, bone and joint, CNS, lower respiratory tract, endocarditis, septicaemia).Population: Adults; paediatric patients for amoebiasis onlyDailyMed (U.S. National Library of Medicine)

• Most common: nausea, headache, anorexia, vomiting, diarrhoea, epigastric distress, metallic taste; also candidiasis overgrowth, dark urine, reversible leucopenia; rarely serious neurological and hypersensitivity reactions.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to metronidazole or other nitroimidazole derivatives; use of disulfiram within the last 2 weeks; alcohol or propylene glycol-containing products during therapy and for at least 3 days afterwards; Cockayne syndrome.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• US boxed warning: metronidazole was carcinogenic in mice and rats; avoid unnecessary use and reserve it for its labelled indications.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Neurological reactions (encephalopathy, peripheral neuropathy, aseptic meningitis, convulsive seizures) have been reported; stop treatment if abnormal neurological signs appear. Severe hepatotoxicity/acute liver failure has occurred in patients with Cockayne syndrome. Severe cutaneous adverse reactions (SJS/TEN, DRESS, AGEP) and QT prolongation have been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Alcohol / propylene glycolDisulfiram-like reaction (abdominal cramps, nausea, vomiting, headache, flushing); avoid during therapy and for at least 3 days afterwards.DailyMed (U.S. National Library of Medicine)
• DisulfiramPsychotic reactions reported; do not give metronidazole to patients who took disulfiram within the last 2 weeks.DailyMed (U.S. National Library of Medicine)
• Warfarin and other oral anticoagulantsPotentiated anticoagulant effect with prolonged prothrombin time; monitor PT/INR.DailyMed (U.S. National Library of Medicine)

• Contraindicated in the first trimester for trichomoniasis; in later pregnancy the single-dose 2 g regimen should not be used. Metronidazole crosses the placenta; use only if clearly needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Metronidazole is present in human milk; the US label says a nursing mother may pump and discard milk during therapy and for 48 hours after the last dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Metronidazole: After passive diffusion into susceptible anaerobes it is reduced intracellularly (via electron-transport proteins such as ferredoxin) to a short-lived nitroso free radical; the reduced drug and free radicals can interact with DNA, inhibiting DNA synthesis and causing DNA degradation and bacterial death; the precise mechanism is not fully established.