سعر كوباجارامون 500 مجم 20 قرص 2024

Copagaramon 500 mg 20 f.c. tabs.: Metronidazole (Copad Pharma).

• Metronidazole is used for anaerobic bacterial infections and protozoal infections (e.g., trichomoniasis, amebiasis, giardiasis) per labeled indications — confirm Copagaramon Egyptian labeled uses.Population: Adults with labeled anaerobic/protozoal infectionsDailyMed (U.S. National Library of Medicine)

• Common: metallic taste, nausea, abdominal discomfort, headache; candidal overgrowth possible.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to metronidazole or other nitroimidazole derivatives; contraindicated in first trimester for trichomoniasis in historical US labeling contexts — follow current local labeling.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Avoid alcohol during and for at least 3 days after therapy (disulfiram-like reaction); CNS adverse effects (neuropathy, encephalopathy) possible; carcinogenic potential noted in animal studies (US boxed warning historically).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Alcohol / alcohol-containing productsMajorDisulfiram-like reaction possible with alcohol during/after metronidazole therapy.DailyMed (U.S. National Library of Medicine)
• WarfarinMajorMetronidazole may potentiate anticoagulant effect of warfarin — monitor INR.DailyMed (U.S. National Library of Medicine)

• Use in pregnancy only if clearly needed per current labeling; historically avoided in first trimester for some indications — confirm Egyptian leaflet pregnancy advice.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Metronidazole: After passive diffusion into susceptible anaerobes it is reduced intracellularly (via electron-transport proteins such as ferredoxin) to a short-lived nitroso free radical; the reduced drug and free radicals can interact with DNA, inhibiting DNA synthesis and causing DNA degradation and bacterial death; the precise mechanism is unclear (US label).