سعر ميثوتريكسات ابيو 50مجم/مل امبول فيال 50 مجم/5 مل 2022

Methotrexate-Ebewe 50 mg/5 ml solution for injection (10 mg/ml; Sandoz, distributed by B.P Pharma), a folate-analogue antimetabolite and immunosuppressant.

• Commonly reported adverse reactions include ulcerative stomatitis, leukopenia, nausea and abdominal distress; other frequent reactions are infection, malaise, fatigue, chills, fever and dizziness.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• History of severe hypersensitivity to methotrexate.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Pregnancy in patients with non-neoplastic diseases.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning: methotrexate can cause embryo-fetal toxicity, including fetal death; for non-neoplastic diseases it is contraindicated in pregnancy. Females and males of reproductive potential should use effective contraception.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Serious and fatal toxicities: myelosuppression, serious infections, renal toxicity, hepatotoxicity (fibrosis, cirrhosis, liver failure), neurotoxicity, gastrointestinal toxicity, pulmonary toxicity, severe dermatologic reactions, secondary malignancies and tumour lysis syndrome. Avoid live vaccines during treatment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Medication errors have caused deaths, most often when methotrexate was taken daily instead of the prescribed weekly regimen; verify the dose and schedule.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Benzyl alcohol-preserved formulations must not be used for intrathecal or high-dose therapy and carry a risk of serious adverse reactions (gasping syndrome) in neonates; use a preservative-free formulation for these uses.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Proton pump inhibitors, NSAIDs (including aspirin), probenecid, penicillins, sulfonamides and other highly protein-bound or antifolate drugsMay increase methotrexate exposure and the risk of severe toxicity; unexpectedly severe, sometimes fatal, gastrointestinal toxicity has occurred with NSAIDs (mainly with high-dose methotrexate). Monitor closely if co-administration cannot be avoided.DailyMed (U.S. National Library of Medicine)
• Nitrous oxide anaesthesiaPotentiates the effect of methotrexate on folate-dependent pathways and may increase severe adverse reactions; avoid nitrous oxide anaesthesia in patients receiving methotrexate.DailyMed (U.S. National Library of Medicine)
• Folic acid or folinic acid productsIn neoplastic diseases, products containing folic acid or its derivatives may decrease the effectiveness of methotrexate (avoid unless clinically indicated); in rheumatoid arthritis, pJIA and psoriasis, folic or folinic acid is given to reduce adverse reactions.DailyMed (U.S. National Library of Medicine)
• TheophyllineMethotrexate increases theophylline concentrations; monitor theophylline levels.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnant women with non-neoplastic diseases; methotrexate can cause embryo-fetal toxicity and fetal death. Verify pregnancy status before starting treatment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Methotrexate: Folate analogue that inhibits dihydrofolic acid reductase, interfering with DNA synthesis, repair and cellular replication; actively proliferating tissues are most sensitive (US label).