سعر ام تي اكس 25مجم/مل فيال 2022

MTX methotrexate 25 mg/ml solution for injection, 20 ml vial (500 mg), Choongwae Pharma (Korea) > General Technology (Egypt); antifolate antineoplastic and immunosuppressant.

• Neoplastic diseases: acute lymphoblastic leukaemia (combination regimens), prophylaxis and treatment of meningeal leukaemia, non-Hodgkin lymphoma, osteosarcoma, breast cancer, squamous cell carcinoma of the head and neck, and gestational trophoblastic neoplasia.Population: Adults and paediatric patients (per indication)DailyMed (U.S. National Library of Medicine)
• Rheumatoid arthritis.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Polyarticular juvenile idiopathic arthritis.Population: Paediatric patientsDailyMed (U.S. National Library of Medicine)

• Commonly reported: ulcerative stomatitis, leukopenia, nausea and abdominal distress; also infection, malaise, fatigue, chills, fever and dizziness; in RA trials elevated liver function tests (15%) and nausea/vomiting (10%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of severe hypersensitivity reactions to methotrexate, including anaphylaxis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Pregnancy in patients with non-neoplastic diseases.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: embryo-fetal toxicity including fetal death; hypersensitivity reactions; benzyl alcohol toxicity; and other serious adverse reactions (myelosuppression, serious infections, renal, hepatic, neurologic, gastrointestinal, pulmonary and dermatologic toxicity).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe, potentially fatal myelosuppression and serious opportunistic infections can occur; withhold, reduce or discontinue as needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Pulmonary toxicity (interstitial pneumonitis) and severe dermatologic reactions (TEN, SJS) can occur at any dose; limit sun exposure (photosensitivity).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• NSAIDs/aspirin, proton pump inhibitors, penicillins, sulfonamides, probenecid and other antifolatesMay increase methotrexate exposure and the risk of severe toxicity (including fatal gastrointestinal toxicity with NSAIDs); monitor closely if coadministration cannot be avoided.DailyMed (U.S. National Library of Medicine)
• Folic acid / folinic acid productsIn neoplastic diseases, folate-containing products may decrease methotrexate effectiveness; in RA, pJIA and psoriasis folic or folinic acid is given to reduce adverse reactions.DailyMed (U.S. National Library of Medicine)
• TheophyllineMethotrexate increases theophylline concentrations; monitor theophylline levels.DailyMed (U.S. National Library of Medicine)

• Can cause embryo-fetal toxicity and fetal death; contraindicated in pregnancy for non-neoplastic diseases; advise pregnant women with neoplastic disease of the risk; females and males of reproductive potential should use effective contraception.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Methotrexate: Folate antagonist that inhibits dihydrofolate reductase, blocking tetrahydrofolate-dependent DNA/RNA and protein synthesis.