سعر اكسفورج اتش سي تي 10/160/25مجم 14 قرص 2024

Amlodipine 10 mg / valsartan 160 mg / hydrochlorothiazide 25 mg oral film-coated tablets (Exforge HCT, Novartis), pack of 14.

• Treatment of hypertension, to lower blood pressure (lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions).Population: AdultsDailyMed (U.S. NLM)
• Treatment of essential hypertension as substitution therapy in adults whose blood pressure is adequately controlled on amlodipine, valsartan and hydrochlorothiazide taken as separate or dual-plus-single formulations.Population: AdultsEuropean Medicines Agency

• Most common adverse events (>=2%): dizziness, peripheral edema, headache, dyspepsia, fatigue, muscle spasms, back pain, nausea and nasopharyngitis.International label, same product · DailyMed (U.S. NLM)

• Anuria; hypersensitivity to other sulfonamide-derived drugs; known hypersensitivity to any component; do not coadminister aliskiren in patients with diabetes.International label, same product · DailyMed (U.S. NLM)
• EU: also second and third trimesters of pregnancy; hepatic impairment, biliary cirrhosis or cholestasis; severe renal impairment (GFR <30), anuria and dialysis; aliskiren in diabetes or GFR <60; refractory hypokalaemia, hyponatraemia, hypercalcaemia and symptomatic hyperuricaemia; severe hypotension; shock; left ventricular outflow obstruction; haemodynamically unstable heart failure after acute MI.International label, same product · European Medicines Agency

• Boxed warning - fetal toxicity: drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as possible when pregnancy is detected.International label, same product · DailyMed (U.S. NLM)
• Hypotension: correct volume or salt depletion before starting; start under close supervision and cautiously in heart failure, recent myocardial infarction, surgery or dialysis.International label, same product · DailyMed (U.S. NLM)
• Worsening angina and acute myocardial infarction can develop after starting or increasing amlodipine, particularly in severe obstructive coronary artery disease.International label, same product · DailyMed (U.S. NLM)

• Moderate and strong CYP3A inhibitorsIncrease amlodipine exposure; may require dose reduction; monitor for hypotension and edema.DailyMed (U.S. NLM)
• CYP3A inducers (e.g. rifampicin, St John's wort)Effect on amlodipine not quantified; monitor blood pressure closely.DailyMed (U.S. NLM)
• SildenafilMonitor for hypotension when coadministered with amlodipine.DailyMed (U.S. NLM)

• Exforge HCT can cause fetal harm; renin-angiotensin system drugs in the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as possible when pregnancy is detected.International label, same product · DailyMed (U.S. NLM)
• Hydrochlorothiazide is present in human milk, valsartan in rat milk and amlodipine reportedly in human milk; because of potential serious adverse reactions in breastfed infants, breastfeeding is not recommended during treatment.International label, same product · DailyMed (U.S. NLM)

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