سعر فورجيناب 10/160/12.5 مجم 10 أقراص مغلفة 2026

Amlodipine 10 mg / valsartan 160 mg / hydrochlorothiazide 12.5 mg film-coated tablets.

• Treatment of hypertension to lower blood pressure (not for initial therapy in the US label; for patients not controlled on two of CCB, ARB and diuretic, or as replacement for individually titrated components).Population: AdultsDailyMed (U.S. NLM)

• Most common (>=2%): dizziness, peripheral oedema, headache, dyspepsia, fatigue, muscle spasms, back pain, nausea and nasopharyngitis.International label, same formulation · DailyMed (U.S. NLM)

• Anuria; hypersensitivity to sulfonamide-derived drugs or any component; do not coadminister aliskiren in patients with diabetes.International label, same formulation · DailyMed (U.S. NLM)

• Boxed warning: fetal toxicity - drugs acting on the renin-angiotensin system can injure or kill the developing fetus; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. NLM)
• Hypotension in volume- or salt-depleted patients; worsening angina or myocardial infarction after starting/increasing amlodipine in severe obstructive CAD; impaired renal function; electrolyte and metabolic disturbances from the thiazide.International label, same formulation · DailyMed (U.S. NLM)

• AliskirenDo not coadminister in patients with diabetes (dual RAS blockade).DailyMed (U.S. NLM)
• Potassium-raising agentsHyperkalaemia risk; monitor potassium.DailyMed (U.S. NLM)
• NSAIDsPossible renal deterioration and reduced antihypertensive effect.DailyMed (U.S. NLM)

• Can cause fetal harm: renin-angiotensin system drugs in the second and third trimesters reduce fetal renal function and increase fetal/neonatal morbidity and death; thiazides cross the placenta (fetal/neonatal jaundice, thrombocytopenia). Discontinue when pregnancy is detected.International label, same formulation · DailyMed (U.S. NLM)
• Breastfeeding not recommended: hydrochlorothiazide is present in human milk, amlodipine reported in human milk and valsartan in rat milk.International label, same formulation · DailyMed (U.S. NLM)

• Amlodipine: Blocks L-type calcium channels in vascular smooth muscle causing vasodilation.
• Valsartan: Blocks AT1 receptors, preventing angiotensin II vasoconstriction and aldosterone release.
• Hydrochlorothiazide: Inhibits Na-Cl reabsorption in the distal convoluted tubule.