سعر كوربريل 2.5 مجم 7 كبسولات 2022

Corpril 2.5 mg capsules, 7 capsules (Global Napi > Rexcel): ramipril.

• Hypertension (to lower blood pressure), alone or with thiazide diuretics.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Risk reduction of MI, stroke, or CV death in patients ≥55 years at high CV risk.Population: Adults ≥55 years high CV riskDailyMed (U.S. National Library of Medicine)
• Stable patients with clinical signs of heart failure post-myocardial infarction.Population: Adults post-MI with HF signsDailyMed (U.S. National Library of Medicine)

• Most common in hypertension: headache, dizziness, fatigue; cough frequently leads to discontinuation.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to ramipril or any ACE inhibitor; history of ACE-inhibitor or hereditary/idiopathic angioedema; combination with a neprilysin inhibitor (e.g. sacubitril) within 36 hours; co-administration of aliskiren in diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: fetal toxicity — discontinue when pregnancy is detected; RAS drugs can injure/kill the developing fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Angioedema (including laryngeal), hypotension, hyperkalemia, renal impairment; avoid dual RAS blockade; cough may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• DiureticsMajorMay cause excessive hypotension after starting ramipril; consider reducing/stopping diuretic or lower starting dose.DailyMed (U.S. National Library of Medicine)
• NSAIDs / COX-2 inhibitorsModerateMay worsen renal function and blunt antihypertensive effect, especially in elderly/volume-depleted/renal impairment.DailyMed (U.S. National Library of Medicine)
• Potassium-sparing agents / potassium supplementsMajorMay cause hyperkalemia; monitor serum potassium.DailyMed (U.S. National Library of Medicine)

• Use of drugs acting on the renin-angiotensin system in the second and third trimesters reduces fetal renal function and increases fetal/neonatal morbidity and death. Discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Ramipril use is not recommended in nursing mothers (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ramipril: Prodrug hydrolysed to ramiprilat, which inhibits ACE, reducing angiotensin II and aldosterone.