سعر فلوكاموكس 1جم فيال 2024

Amoxicillin + flucloxacillin powder for solution for injection (vial) (Amoxicillin 500 mg / flucloxacillin 500 mg per vial (1 g)), a combination of a broad-spectrum aminopenicillin and a penicillinase-resistant penicillin.

• Flucloxacillin: common minor gastrointestinal disturbances; uncommon rash, urticaria and purpura; very rare hepatitis and cholestatic jaundice, neutropenia, thrombocytopenia, anaphylaxis, pseudomembranous colitis and Stevens-Johnson syndrome/toxic epidermal necrolysis.General active-ingredient information · emc (medicines.org.uk)

• Flucloxacillin: hypersensitivity to flucloxacillin or other beta-lactam antibiotics (penicillins, cephalosporins); previous flucloxacillin-associated jaundice or hepatic dysfunction.General active-ingredient information · emc (medicines.org.uk)
• Amoxicillin: hypersensitivity to amoxicillin or any penicillin; history of severe immediate hypersensitivity (e.g. anaphylaxis) to another beta-lactam (cephalosporin, carbapenem or monobactam).General active-ingredient information · emc (medicines.org.uk)

• Flucloxacillin can cause hepatitis and cholestatic jaundice, which may be delayed up to two months after treatment and may be severe; use with caution in hepatic dysfunction, in patients over 50 years and in serious underlying disease.General active-ingredient information · emc (medicines.org.uk)
• Serious and occasionally fatal hypersensitivity reactions (anaphylaxis) can occur with beta-lactams; enquire about previous reactions before treatment. Acute generalised exanthematous pustulosis requires discontinuation.General active-ingredient information · emc (medicines.org.uk)
• Caution with concomitant paracetamol because of the risk of high anion gap metabolic acidosis, especially in severe renal impairment, sepsis or malnutrition.General active-ingredient information · emc (medicines.org.uk)
• In neonates, high-dose flucloxacillin may displace bilirubin from plasma proteins and predispose to kernicterus in jaundiced babies.General active-ingredient information · emc (medicines.org.uk)
• Amoxicillin: avoid if infectious mononucleosis is suspected (morbilliform rash); convulsions may occur with renal impairment or high doses; adjust dose in renal impairment; maintain adequate fluid intake at high doses (crystalluria); antibiotic-associated colitis may occur.General active-ingredient information · emc (medicines.org.uk)

• ParacetamolConcomitant use has been associated with high anion gap metabolic acidosis, especially in patients with risk factors.emc (medicines.org.uk)
• MethotrexateFlucloxacillin reduces methotrexate excretion, which can cause methotrexate toxicity.emc (medicines.org.uk)
• VoriconazoleFlucloxacillin has been reported to significantly decrease plasma voriconazole concentrations; monitor for loss of effect.emc (medicines.org.uk)
• ProbenecidProbenecid slows the renal excretion of flucloxacillin.emc (medicines.org.uk)
• AllopurinolConcurrent allopurinol may increase the likelihood of allergic skin reactions.emc (medicines.org.uk)
• Oral anticoagulants (warfarin, acenocoumarol)Increased INR has been reported; monitor prothrombin time or INR when amoxicillin is added or withdrawn.emc (medicines.org.uk)

• Flucloxacillin: animal studies showed no teratogenic effects and limited human data show no untoward effects; use in pregnancy only when the potential benefit outweighs the risk.General active-ingredient information · emc (medicines.org.uk)
• Flucloxacillin: trace amounts appear in breast milk; consider possible hypersensitivity in the breast-fed infant.General active-ingredient information · emc (medicines.org.uk)

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