سعر فانجيكلير 200مجم 2 كبسولة 2024

Fluconazole 200 mg oral capsules, pack of 2; a triazole antifungal.

• Cryptococcal meningitis (treatment) and prophylaxis of relapse in patients at high risk of recurrencePopulation: Adultselectronic medicines compendium (emc), MHRA-authorised SmPC
• Invasive candidiasis and coccidioidomycosisPopulation: Adultselectronic medicines compendium (emc), MHRA-authorised SmPC
• Mucosal candidiasis including oropharyngeal and oesophageal candidiasis, candiduria and chronic mucocutaneous candidiasisPopulation: Adultselectronic medicines compendium (emc), MHRA-authorised SmPC

• Most frequent (1-10%): headache, abdominal pain, diarrhoea, nausea, vomiting, raised ALT/AST/alkaline phosphatase, and rash.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC

• Hypersensitivity to fluconazole, related azoles or any excipient.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC
• Coadministration of QT-prolonging drugs metabolised by CYP3A4 (such as cisapride, astemizole, pimozide, quinidine and erythromycin); terfenadine is contraindicated with fluconazole doses of 400 mg/day or more.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC

• Rare cases of serious hepatic toxicity, including fatalities, mainly in patients with serious underlying conditions; monitor patients who develop abnormal liver tests and stop if signs of liver disease appear.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC
• Very rare QT prolongation and torsades de pointes; use with caution in patients with proarrhythmic conditions.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC
• Exfoliative skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) and DRESS have been reported; stop treatment if a rash attributable to fluconazole develops in a patient treated for a superficial infection.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC

• CYP2C9, CYP2C19 and CYP3A4 substratesFluconazole is a moderate CYP2C9 and CYP3A4 inhibitor and a strong CYP2C19 inhibitor; it can raise plasma levels of drugs metabolised by these enzymes.DailyMed (U.S. National Library of Medicine)

• Observational studies suggest an increased risk of spontaneous abortion with fluconazole in the first and/or second trimester; cumulative doses of 150 mg or less in the first trimester showed no increase in overall malformation risk. Women of childbearing potential should be informed of the potential fetal risk.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC
• Fluconazole passes into breast milk at concentrations similar to plasma; breastfeeding may continue after a single 150 mg dose but is not recommended after repeated or high-dose use.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC

• Fluconazole: Inhibits fungal cytochrome P450-dependent 14-alpha-lanosterol demethylation, blocking ergosterol synthesis.