سعر فلوكازول 50 مجم 7 كبسولات 2022

Fluconazole 50 mg capsules, pack of 7, by Spimaco (Saudi Arabia), distributed in Egypt by EIMC; triazole antifungal.

• Adults: treatment of cryptococcal meningitis, coccidioidomycosis, invasive candidiasis, mucosal candidiasis (oropharyngeal, oesophageal, candiduria, chronic mucocutaneous), chronic oral atrophic candidiasis, acute or recurrent vaginal candidiasis and candidal balanitis when local therapy is not appropriate, dermatomycosis when systemic therapy is indicated, and onychomycosis when other agents are not appropriate.Population: Adultselectronic medicines compendium (eMC)
• Adults: prophylaxis of relapse of cryptococcal meningitis, of relapse of oropharyngeal or oesophageal candidiasis in HIV patients, of recurrent vaginal candidiasis (4 or more episodes a year), and of candidal infections in prolonged neutropenia.Population: Adultselectronic medicines compendium (eMC)
• Children 0 to 17 years: mucosal and invasive candidiasis, cryptococcal meningitis, prophylaxis of candidal infections in immunocompromised patients, and maintenance therapy to prevent relapse of cryptococcal meningitis.Population: Children 0-17 yearselectronic medicines compendium (eMC)

• Most common (1-10%): headache, abdominal pain, diarrhoea, nausea, vomiting, raised ALT, AST and alkaline phosphatase, and rash.International label, equivalent formulation · electronic medicines compendium (eMC)
• Uncommon to rare: anaemia, agranulocytosis, anaphylaxis, seizures, dizziness, taste perversion, QT prolongation, torsades de pointes, cholestasis, hepatic failure, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema and alopecia; DRESS (frequency not known).International label, equivalent formulation · electronic medicines compendium (eMC)

• Hypersensitivity to fluconazole, related azoles or any excipient.International label, equivalent formulation · electronic medicines compendium (eMC)
• Co-administration of terfenadine in patients receiving multiple doses of 400 mg per day or more.International label, equivalent formulation · electronic medicines compendium (eMC)
• Co-administration of QT-prolonging medicines metabolised by CYP3A4, such as cisapride, astemizole, pimozide, quinidine and erythromycin.International label, equivalent formulation · electronic medicines compendium (eMC)

• Rare serious hepatotoxicity, including fatalities, mainly in patients with serious underlying conditions; monitor patients with abnormal liver tests and stop treatment if signs of liver injury develop.International label, equivalent formulation · electronic medicines compendium (eMC)
• QT prolongation and very rare torsades de pointes; use with caution in potentially proarrhythmic conditions (e.g. hypokalaemia, advanced heart failure).International label, equivalent formulation · electronic medicines compendium (eMC)
• Rare exfoliative skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) and DRESS; stop treatment if a rash attributable to fluconazole develops in a superficial infection.International label, equivalent formulation · electronic medicines compendium (eMC)

• Cisapride, astemizole, pimozide, quinidine, erythromycin; terfenadine (with fluconazole 400 mg/day or more)Contraindicated: risk of QT prolongation and torsades de pointes.electronic medicines compendium (eMC)
• Warfarin and other coumarin anticoagulantsProthrombin time prolonged up to 2-fold with bleeding events; monitor prothrombin time.electronic medicines compendium (eMC)
• Short-acting benzodiazepines (midazolam, triazolam)Substantial increases in levels and psychomotor effects; consider dose reduction and monitoring.electronic medicines compendium (eMC)

• Observational studies suggest an increased risk of spontaneous abortion with use in the first and/or second trimester; cumulative first-trimester doses of 150 mg or less showed no increase in the overall risk of malformations, but a small increased risk of musculoskeletal malformations was found; women of childbearing potential should be informed of the risk and a 1-week washout after a single dose is recommended before pregnancy.International label, equivalent formulation · electronic medicines compendium (eMC)
• Fluconazole passes into breast milk at concentrations similar to plasma; breastfeeding may continue after a single 150 mg dose but is not recommended after repeated or high-dose use.International label, equivalent formulation · electronic medicines compendium (eMC)

• Fluconazole: Inhibits fungal cytochrome P-450-mediated 14-alpha-lanosterol demethylation, an essential step in ergosterol biosynthesis (UK Diflucan SmPC, section 5.1).