سعر اترافنجكس 10 مجم/مل سائل شراب 150 مل 2022

Itraconazole 10 mg/ml oral liquid, a triazole antifungal used for oropharyngeal and oesophageal candidiasis.

• Oropharyngeal and oesophageal candidiasis.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: nausea (11%), diarrhoea (11%), vomiting (7%), fever (7%), abdominal pain (6%), cough, rash and headache.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Do not use in patients with evidence of ventricular dysfunction such as congestive heart failure or a history of CHF, except for life-threatening or other serious infections.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Co-administration with certain CYP3A4 substrates is contraindicated because of increased plasma concentrations and risk of serious reactions (e.g. QT prolongation, torsades de pointes): including methadone, disopyramide, dofetilide, dronedarone, quinidine, ergot alkaloids, irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, lovastatin and simvastatin (see the full label list).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: congestive heart failure, cardiac effects and serious drug interactions with CYP3A4 substrates (QT prolongation, ventricular tachyarrhythmias).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Rare serious hepatotoxicity including liver failure; monitor liver function.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A4 substrates (e.g. simvastatin, lovastatin, midazolam, triazolam, pimozide, quinidine, dofetilide)Itraconazole is a strong CYP3A4 inhibitor and raises their concentrations; several are contraindicated.DailyMed (U.S. National Library of Medicine)

• Use in pregnancy only if the benefit outweighs the potential risk to the fetus; women of reproductive potential should use effective contraception during treatment and for 2 months after.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Itraconazole is excreted in human milk; weigh the benefit of treatment against the risk to the infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Itraconazole: Triazole antifungal; inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase (ergosterol synthesis); also a strong inhibitor of CYP3A4, P-glycoprotein and BCRP.