سعر جينكيستار 320 مجم 7 قرص 2022

Gemifloxacin 320 mg film-coated tablets, pack of 7 (fluoroquinolone antibacterial).

• Acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, H. influenzae, H. parainfluenzae or M. catarrhalis; reserve for patients with no alternative treatment options.Population: Adults (18 years and older)DailyMed (U.S. National Library of Medicine)
• Community-acquired pneumonia of mild to moderate severity caused by susceptible organisms, including multi-drug-resistant S. pneumoniae.Population: Adults (18 years and older)DailyMed (U.S. National Library of Medicine)

• Most common (>=2%) with 320 mg in trials: diarrhoea 5.0%, headache 4.2%, nausea 3.7%, rash 3.5%, abdominal pain 2.2%.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to gemifloxacin, fluoroquinolone antibiotics or any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: disabling and potentially irreversible serious reactions (tendinitis and tendon rupture, peripheral neuropathy, CNS effects) that can occur together; may exacerbate muscle weakness in myasthenia gravis (avoid in known myasthenia gravis). Discontinue at the first sign.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• May prolong the QT interval: avoid with QTc prolongation history, uncorrected hypokalaemia or hypomagnesaemia, or class IA/III antiarrhythmics; use with caution with other QT-prolonging drugs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Rash occurred more often than with comparators (2.7% vs 0.6%), more frequently in patients under 40, women, women on hormone replacement therapy and with longer courses; discontinue if rash or urticaria develops.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Aluminium/magnesium antacids, iron, zinc or metal-containing multivitamins, didanosineCoadministration with an Al/Mg antacid reduced gemifloxacin AUC by 85%; separate doses (gemifloxacin 3 hours before or 2 hours after).DailyMed (U.S. National Library of Medicine)
• SucralfateSucralfate given 3 hours before reduced gemifloxacin AUC by 53%; give gemifloxacin at least 2 hours before sucralfate.DailyMed (U.S. National Library of Medicine)
• ProbenecidProbenecid increased gemifloxacin AUC by about 45%.DailyMed (U.S. National Library of Medicine)

• Safety in pregnant women has not been established; do not use in pregnancy unless the potential benefit outweighs the risk to the fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Excreted in rat milk; no human data. Do not use in lactating women unless the benefit to the mother outweighs the risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Gemifloxacin: Inhibits bacterial DNA synthesis by inhibiting DNA gyrase and topoisomerase IV.